Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Bindu D. Paul; Andrew A. Pieper

doi:10.3390/biom14020155

Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Bindu D. Paul, Andrew A. Pieper

School of Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.

Original language	English (US)
Article number	155
Journal	Biomolecules
Volume	14
Issue number	2
DOIs	https://doi.org/10.3390/biom14020155
State	Published - Feb 2024

Keywords

bilirubin
biliverdin reductase
cognition
lipophilic antioxidant
superoxide

ASJC Scopus subject areas

Molecular Biology
Biochemistry

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10.3390/biom14020155

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title = "Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain",

abstract = "Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.",

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AU - Pieper, Andrew A.

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N2 - Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.

AB - Biliverdin reductase-A (BVRA) is a multi-functional enzyme with a multitude of important roles in physiologic redox homeostasis. Classically, BVRA is well known for converting the heme metabolite biliverdin to bilirubin, which is a potent antioxidant in both the periphery and the brain. However, BVRA additionally participates in many neuroprotective signaling cascades in the brain that preserve cognition. Here, we review the neuroprotective roles of BVRA and bilirubin in the brain, which together constitute a BVRA/bilirubin axis that influences healthy aging and cognitive function.

KW - bilirubin

KW - biliverdin reductase

KW - cognition

KW - lipophilic antioxidant

KW - superoxide

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Neuroprotective Roles of the Biliverdin Reductase-A/Bilirubin Axis in the Brain

Abstract

Keywords

ASJC Scopus subject areas

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