Neuroprotection in metabolism-based therapy

Adam L. Hartman

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Metabolism-based therapy has been used successfully in the treatment of seizures but study of its use in other neurodegenerative disorders is growing. Data demonstrating the use of different forms of metabolism-based therapy in human trials of Alzheimer disease and Parkinson disease are discussed. Animal and in vitro studies have shed light on metabolism-based therapy's mechanisms in these diseases, as well as ALS, aging, ischemia, trauma and mitochondrial cytopathies. Additional insights may be obtained by considering the role of metabolism-based therapy in cell disability and death (specifically apoptosis, excitotoxicity, and autophagy).

Original languageEnglish (US)
Pages (from-to)286-294
Number of pages9
JournalEpilepsy Research
Issue number3
StatePublished - Jul 2012


  • Alzheimer disease
  • Calorie restriction
  • Epilepsy
  • Ketogenic diet
  • Neuroprotection
  • Parkinson disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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