Neuroprotection in acute brain injury: An up-to-date review

Nino Stocchetti; Fabio S. Taccone; Giuseppe Citerio; Paul E. Pepe; Peter D. Roux; Mauro Oddo; Kees H. Polderman; Robert D. Stevens; William Barsan; Andrew I.R. Maas; Geert Meyfroidt; Michael J. Bell; Robert Silbergleit; Paul M. Vespa; Alan I. Faden; Raimund Helbok; Samuel Tisherman; Elisa R. Zanier; Terence Valenzuela; Julia Wendon; David K. Menon; Jean Louis Vincent

doi:10.1186/s13054-015-0887-8

Neuroprotection in acute brain injury: An up-to-date review

Nino Stocchetti, Fabio S. Taccone, Giuseppe Citerio, Paul E. Pepe, Peter D. Roux, Mauro Oddo, Kees H. Polderman, Robert D. Stevens, William Barsan, Andrew I.R. Maas, Geert Meyfroidt, Michael J. Bell, Robert Silbergleit, Paul M. Vespa, Alan I. Faden, Raimund Helbok, Samuel Tisherman, Elisa R. Zanier, Terence Valenzuela, Julia WendonDavid K. Menon, Jean Louis Vincent

School of Medicine

Research output: Contribution to journal › Review article › peer-review

77 Scopus citations

Abstract

Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

Original language	English (US)
Article number	186
Journal	Critical Care
Volume	19
Issue number	1
DOIs	https://doi.org/10.1186/s13054-015-0887-8
State	Published - Apr 21 2015

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

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Stocchetti, N., Taccone, F. S., Citerio, G., Pepe, P. E., Roux, P. D., Oddo, M., Polderman, K. H., Stevens, R. D., Barsan, W., Maas, A. I. R., Meyfroidt, G., Bell, M. J., Silbergleit, R., Vespa, P. M., Faden, A. I., Helbok, R., Tisherman, S., Zanier, E. R., Valenzuela, T., ... Vincent, J. L. (2015). Neuroprotection in acute brain injury: An up-to-date review. Critical Care, 19(1), Article 186. https://doi.org/10.1186/s13054-015-0887-8

Stocchetti, N, Taccone, FS, Citerio, G, Pepe, PE, Roux, PD, Oddo, M, Polderman, KH, Stevens, RD, Barsan, W, Maas, AIR, Meyfroidt, G, Bell, MJ, Silbergleit, R, Vespa, PM, Faden, AI, Helbok, R, Tisherman, S, Zanier, ER, Valenzuela, T, Wendon, J, Menon, DK & Vincent, JL 2015, 'Neuroprotection in acute brain injury: An up-to-date review', Critical Care, vol. 19, no. 1, 186. https://doi.org/10.1186/s13054-015-0887-8

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abstract = "Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.",

author = "Nino Stocchetti and Taccone, {Fabio S.} and Giuseppe Citerio and Pepe, {Paul E.} and Roux, {Peter D.} and Mauro Oddo and Polderman, {Kees H.} and Stevens, {Robert D.} and William Barsan and Maas, {Andrew I.R.} and Geert Meyfroidt and Bell, {Michael J.} and Robert Silbergleit and Vespa, {Paul M.} and Faden, {Alan I.} and Raimund Helbok and Samuel Tisherman and Zanier, {Elisa R.} and Terence Valenzuela and Julia Wendon and Menon, {David K.} and Vincent, {Jean Louis}",

note = "Funding Information: PDLR receives research funding from Integra Lifesciences, Neurologica, the Dana Foundation and the National Institutes of Health; is a consultant for Integra Lifesciences, Codman, Synthes, and Neurologica; and is a member of the scientific advisory board of Cerebrotech, Brainsgate, Orsan, and Edge Therapeutics. MO is supported by grants from the Swiss National Science Foundation (grant number 320030_138191) and the Novartis Foundation for Biomedical Research. MJB reports receipt of National Institutes of Health grant U01 NS081041. ST is co-author on the patent 'Emergency Preservation and Resuscitation Method'. The remaining authors declare that they have no competing interests. Publisher Copyright: {\textcopyright} Stocchetti et al.; licensee BioMed Central.",

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AU - Taccone, Fabio S.

AU - Citerio, Giuseppe

AU - Pepe, Paul E.

AU - Roux, Peter D.

AU - Oddo, Mauro

AU - Polderman, Kees H.

AU - Stevens, Robert D.

AU - Barsan, William

AU - Maas, Andrew I.R.

AU - Meyfroidt, Geert

AU - Bell, Michael J.

AU - Silbergleit, Robert

AU - Vespa, Paul M.

AU - Faden, Alan I.

AU - Helbok, Raimund

AU - Tisherman, Samuel

AU - Zanier, Elisa R.

AU - Valenzuela, Terence

AU - Wendon, Julia

AU - Menon, David K.

AU - Vincent, Jean Louis

N1 - Funding Information: PDLR receives research funding from Integra Lifesciences, Neurologica, the Dana Foundation and the National Institutes of Health; is a consultant for Integra Lifesciences, Codman, Synthes, and Neurologica; and is a member of the scientific advisory board of Cerebrotech, Brainsgate, Orsan, and Edge Therapeutics. MO is supported by grants from the Swiss National Science Foundation (grant number 320030_138191) and the Novartis Foundation for Biomedical Research. MJB reports receipt of National Institutes of Health grant U01 NS081041. ST is co-author on the patent 'Emergency Preservation and Resuscitation Method'. The remaining authors declare that they have no competing interests. Publisher Copyright: © Stocchetti et al.; licensee BioMed Central.

PY - 2015/4/21

Y1 - 2015/4/21

N2 - Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

AB - Neuroprotective strategies that limit secondary tissue loss and/or improve functional outcomes have been identified in multiple animal models of ischemic, hemorrhagic, traumatic and nontraumatic cerebral lesions. However, use of these potential interventions in human randomized controlled studies has generally given disappointing results. In this paper, we summarize the current status in terms of neuroprotective strategies, both in the immediate and later stages of acute brain injury in adults. We also review potential new strategies and highlight areas for future research.

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Neuroprotection in acute brain injury: An up-to-date review

Abstract

ASJC Scopus subject areas

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