Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins

Roman J. Giger, Jean François Cloutier, Amar Sahay, Rabinder K. Prinjha, Dorothy V. Levengood, Stephen E. Moore, Susan Pickering, David Simmons, Sohaila Rastan, Frank S. Walsh, Alex L. Kolodkin, David D. Ginty, Martin Geppert

Research output: Contribution to journalArticlepeer-review

341 Scopus citations


Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn- 2 in axon guidance events throughout neural development. Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.

Original languageEnglish (US)
Pages (from-to)29-41
Number of pages13
Issue number1
StatePublished - Jan 2000

ASJC Scopus subject areas

  • Neuroscience(all)


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