@article{e43cfae20f1d4ee1b4cc8f9556a87fe0,
title = "Neuropilin-2 is required in vivo for selective axon guidance responses to secreted semaphorins",
abstract = "Neuropilins are receptors for class 3 secreted semaphorins, most of which can function as potent repulsive axon guidance cues. We have generated mice with a targeted deletion in the neuropilin-2 (Npn-2) locus. Many Npn-2 mutant mice are viable into adulthood, allowing us to assess the role of Npn- 2 in axon guidance events throughout neural development. Npn-2 is required for the organization and fasciculation of several cranial nerves and spinal nerves. In addition, several major fiber tracts in the brains of adult mutant mice are either severely disorganized or missing. Our results show that Npn-2 is a selective receptor for class 3 semaphorins in vivo and that Npn-1 and Npn-2 are required for development of an overlapping but distinct set of CNS and PNS projections.",
author = "Giger, {Roman J.} and Cloutier, {Jean Fran{\c c}ois} and Amar Sahay and Prinjha, {Rabinder K.} and Levengood, {Dorothy V.} and Moore, {Stephen E.} and Susan Pickering and David Simmons and Sohaila Rastan and Walsh, {Frank S.} and Kolodkin, {Alex L.} and Ginty, {David D.} and Martin Geppert",
note = "Funding Information: We thank W. Stallcup for generously providing the F84.1 antibodies, M. Tessier-Lavigne and S. Strittmatter for APSema3C expression plasmids, and Mark Molliver and members of the Ginty and Kolodkin laboratories for helpful discussions. Npn-2 mutant mice are the property of SmithKline Beecham Pharmaceuticals, and requests for these mice should be directed to F. S. W. This work was supported by the National Institutes of Health/National Institutes of Mental Health-R01MH59199 (D. D. G. and A. L. K.), the National Alliance for Research on Schizophrenia and Depression and Schweizerischen Nationalfonds (R. J. G.), the Medical Research Council of Canada (J.-F. C.), and a grant from SmithKline Beecham Neuroscience (R. G., D. D. G., and A. L. K.).",
year = "2000",
month = jan,
doi = "10.1016/S0896-6273(00)80869-7",
language = "English (US)",
volume = "25",
pages = "29--41",
journal = "Neuron",
issn = "0896-6273",
publisher = "Cell Press",
number = "1",
}