Neuropeptide Y expression distinguishes malignant from benign pheochromocytoma

L. J. Helman, P. S. Cohen, S. D. Averbuch, M. J. Cooper, H. R. Keiser, M. A. Israel

Research output: Contribution to journalArticlepeer-review

57 Scopus citations


No reliable gross or microscopic features distinguish benign from malignant pheochromocytomas. The diagnosis of malignant pheochromocytoma is based solely on the presence of regional or distant metastases. This study evaluated the expression of neuropeptide Y messenger RNA (mRNA) in nine benign and 11 malignant pheochromocytomas and has found that neuropeptide Y mRNA was expressed in all nine benign tumors but in only four of 11 malignant tumors (P = .0084). These data suggest that the determination of neuropeptide Y expression in the evaluation of patients with pheochromocytoma may have prognostic significance.

Original languageEnglish (US)
Pages (from-to)1720-1725
Number of pages6
JournalJournal of Clinical Oncology
Issue number11
StatePublished - Jan 1 1989

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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