Neuropeptide modulation of murine erythropoiesis.

R. R. Skelly, J. Fata, S. J. Sharkis, L. Sensenbrenner, A. A. Ansari

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells.

Original languageEnglish (US)
Pages (from-to)324-330
Number of pages7
JournalAnnals of Clinical and Laboratory Science
Issue number5
StatePublished - Sep 1 1987

ASJC Scopus subject areas

  • Microbiology
  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology
  • Molecular Biology
  • Hematology
  • Clinical Biochemistry
  • Medical Laboratory Technology


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