Neuropeptide modulation of murine erythropoiesis.

R. R. Skelly; J. Fata; S. J. Sharkis; L. Sensenbrenner; A. A. Ansari

Neuropeptide modulation of murine erythropoiesis.

R. R. Skelly, J. Fata, S. J. Sharkis, L. Sensenbrenner, A. A. Ansari

School of Medicine

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells.

Original language	English (US)
Pages (from-to)	324-330
Number of pages	7
Journal	Annals of Clinical and Laboratory Science
Volume	17
Issue number	5
State	Published - Sep 1 1987

ASJC Scopus subject areas

Microbiology
Immunology and Allergy
Pathology and Forensic Medicine
Immunology
Molecular Biology
Hematology
Clinical Biochemistry
Medical Laboratory Technology

Cite this

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AU - Skelly, R. R.

AU - Fata, J.

AU - Sharkis, S. J.

AU - Sensenbrenner, L.

AU - Ansari, A. A.

PY - 1987/9/1

Y1 - 1987/9/1

N2 - Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells.

AB - Neuropeptide modulation of hematopoietic stem cell differentiation was studied in an in vitro murine system. Endorphins were able to influence the erythropoietin-dependent differentiation of bone marrow cells into erythroid colony forming units in a dose dependent manner. The effects on progenitor cell maturation were influenced by the conditions and time of exposure to the endorphins. The modulation of erythropoiesis by the endorphins suggests that these peptides may function as modifiers of the maturation of bone marrow cells.

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JO - Annals of Clinical and Laboratory Science

JF - Annals of Clinical and Laboratory Science

IS - 5

ER -

Neuropeptide modulation of murine erythropoiesis.

Abstract

ASJC Scopus subject areas

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