Neuronanotechnology for brain regeneration

Kevin Liaw, Zhi Zhang, Sujatha Kannan

Research output: Contribution to journalReview articlepeer-review

2 Scopus citations


Identifying and harnessing regenerative pathways while suppressing the growth-inhibiting processes of the biological response to injury is the central goal of stimulating neurogenesis after central nervous system (CNS) injury. However, due to the complexity of the mature CNS involving a plethora of cellular pathways and extracellular cues, as well as difficulties in accessibility without highly invasive procedures, clinical successes of regenerative medicine for CNS injuries have been extremely limited. Current interventions primarily focus on stabilization and mitigation of further neuronal death rather than direct stimulation of neurogenesis. In the past few decades, nanotechnology has offered substantial innovations to the field of regenerative medicine. Their nanoscale features allow for the fine tuning of biological interactions for enhancing drug delivery and stimulating cellular processes. This review gives an overview of nanotechnology applications in CNS regeneration organized according to cellular and extracellular targets and discuss future directions for the field.

Original languageEnglish (US)
Pages (from-to)3-18
Number of pages16
JournalAdvanced Drug Delivery Reviews
StatePublished - Aug 2019


  • Brain injury
  • Extracellular matrix
  • Nanotechnology
  • Neurogenesis
  • Regenerative medicine
  • Targeted drug delivery

ASJC Scopus subject areas

  • Pharmaceutical Science


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