Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey

Howard S. Ying; Karoline Fackelmann; Ahmed Messoudi; Xiao fang Tang; Jean A. Büttner-Ennever; Anja K.E. Horn

doi:10.1016/S0079-6123(08)00602-X

Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey

Howard S. Ying, Karoline Fackelmann, Ahmed Messoudi, Xiao fang Tang, Jean A. Büttner-Ennever, Anja K.E. Horn

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

5 Scopus citations

Abstract

Motoneurons of the oculomotor nucleus subserving multiply innervated muscle fibres (MIF) receive different afferent inputs from the motoneurons subserving singly innervated muscle fibres (SIF). We asked whether MIF and SIF motoneurons have different neurotransmitter signalling expression profiles. Adult rhesus monkey extraocular muscles were injected with the retrograde tracer cholera toxin. Sections were then stained for various neurotransmitter-signalling markers. MIF motoneurons showed less glutamate receptor 4 (GluR4) and N-methyl-d-aspartate receptor 1 (NMDAR1) immunoreactivity, but showed similar amounts of glutamic acid decarboxylase (GAD) immunoreactive afferent terminals, compared to SIF motoneurons. This difference in excitatory neurotransmitter receptor expression may explain selective oculomotor deficits and allow development of selective pharmacotherapy in the future.

Original language	English (US)
Title of host publication	Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever
Publisher	Elsevier
Pages	13-16
Number of pages	4
ISBN (Print)	9780444531636
DOIs	https://doi.org/10.1016/S0079-6123(08)00602-X
State	Published - 2008

Publication series

Name	Progress in Brain Research
Volume	171
ISSN (Print)	0079-6123

Keywords

AMPA
C-group
GABA
S-group
non-NMDA
non-twitch muscle fibre
twitch muscle fibre

ASJC Scopus subject areas

General Neuroscience

Access to Document

10.1016/S0079-6123(08)00602-X

Cite this

Ying, H. S., Fackelmann, K., Messoudi, A., Tang, X. F., Büttner-Ennever, J. A., & Horn, A. K. E. (2008). Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey. In Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever (pp. 13-16). (Progress in Brain Research; Vol. 171). Elsevier. https://doi.org/10.1016/S0079-6123(08)00602-X

Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey. / Ying, Howard S.; Fackelmann, Karoline; Messoudi, Ahmed et al.
Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Elsevier, 2008. p. 13-16 (Progress in Brain Research; Vol. 171).

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Ying, HS, Fackelmann, K, Messoudi, A, Tang, XF, Büttner-Ennever, JA & Horn, AKE 2008, Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey. in Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Progress in Brain Research, vol. 171, Elsevier, pp. 13-16. https://doi.org/10.1016/S0079-6123(08)00602-X

Ying HS, Fackelmann K, Messoudi A, Tang XF, Büttner-Ennever JA, Horn AKE. Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey. In Using Eye Movements as an Experimental Probe of Brain function A Symposium in Honor of Jean Buttner-Ennever. Elsevier. 2008. p. 13-16. (Progress in Brain Research). doi: 10.1016/S0079-6123(08)00602-X

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abstract = "Motoneurons of the oculomotor nucleus subserving multiply innervated muscle fibres (MIF) receive different afferent inputs from the motoneurons subserving singly innervated muscle fibres (SIF). We asked whether MIF and SIF motoneurons have different neurotransmitter signalling expression profiles. Adult rhesus monkey extraocular muscles were injected with the retrograde tracer cholera toxin. Sections were then stained for various neurotransmitter-signalling markers. MIF motoneurons showed less glutamate receptor 4 (GluR4) and N-methyl-d-aspartate receptor 1 (NMDAR1) immunoreactivity, but showed similar amounts of glutamic acid decarboxylase (GAD) immunoreactive afferent terminals, compared to SIF motoneurons. This difference in excitatory neurotransmitter receptor expression may explain selective oculomotor deficits and allow development of selective pharmacotherapy in the future.",

keywords = "AMPA, C-group, GABA, S-group, non-NMDA, non-twitch muscle fibre, twitch muscle fibre",

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AU - Büttner-Ennever, Jean A.

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AB - Motoneurons of the oculomotor nucleus subserving multiply innervated muscle fibres (MIF) receive different afferent inputs from the motoneurons subserving singly innervated muscle fibres (SIF). We asked whether MIF and SIF motoneurons have different neurotransmitter signalling expression profiles. Adult rhesus monkey extraocular muscles were injected with the retrograde tracer cholera toxin. Sections were then stained for various neurotransmitter-signalling markers. MIF motoneurons showed less glutamate receptor 4 (GluR4) and N-methyl-d-aspartate receptor 1 (NMDAR1) immunoreactivity, but showed similar amounts of glutamic acid decarboxylase (GAD) immunoreactive afferent terminals, compared to SIF motoneurons. This difference in excitatory neurotransmitter receptor expression may explain selective oculomotor deficits and allow development of selective pharmacotherapy in the future.

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Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey

Abstract

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Keywords

ASJC Scopus subject areas

Access to Document

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