TY - JOUR
T1 - Neuronal pattern correlates with the severity of human immunodeficiency virus-associated dementia complex
T2 - Usefulness of spatial pattern analysis in clinicopathological studies
AU - Asare, Enoch
AU - Dunn, Graham
AU - Glass, Jonathan
AU - McArthur, Justin
AU - Luthert, Philip
AU - Lantos, Peter
AU - Everall, Ian
N1 - Copyright:
Copyright 2021 Elsevier B.V., All rights reserved.
PY - 1996/1
Y1 - 1996/1
N2 - The spatial distributional pattern of neurons, in the superior frontal gyrus of 32 subjects who died of acquired immune deficiency syndrome, was examined. The patients were classified as nondemented, mildly demented, and severely demented, and some were treated with the anti-retroviral drug zidovudine. Spatial statistical techniques were employed to investigate the degree of clustering in the individual cases and various groups. We found that the cluster pattern of large and small neurons differed significantly with increasing severity of dementia but was not influenced by the duration of zidovudine treatment. We conclude that this is a sensitive technique for clinicopathological correlations and that the differences may result from loss of specific neuronal populations, which could determine the degree of dementia.
AB - The spatial distributional pattern of neurons, in the superior frontal gyrus of 32 subjects who died of acquired immune deficiency syndrome, was examined. The patients were classified as nondemented, mildly demented, and severely demented, and some were treated with the anti-retroviral drug zidovudine. Spatial statistical techniques were employed to investigate the degree of clustering in the individual cases and various groups. We found that the cluster pattern of large and small neurons differed significantly with increasing severity of dementia but was not influenced by the duration of zidovudine treatment. We conclude that this is a sensitive technique for clinicopathological correlations and that the differences may result from loss of specific neuronal populations, which could determine the degree of dementia.
UR - http://www.scopus.com/inward/record.url?scp=0030051162&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030051162&partnerID=8YFLogxK
M3 - Article
C2 - 8546220
AN - SCOPUS:0030051162
SN - 0002-9440
VL - 148
SP - 31
EP - 38
JO - American Journal of Pathology
JF - American Journal of Pathology
IS - 1
ER -