Neuronal Hormones and the Sympathetic/Parasympathetic Regulation of the Heart

M. J. Ranek, A. Vu, M. S. Willis, A. Lymperopoulos

Research output: Chapter in Book/Report/Conference proceedingChapter


The primary purpose of the heart is to contract and pump blood to the entire body and all peripheral organs. Heart rate and cardiac output are tightly regulated so the heart can adjust to meet the needs of the organism under any given circumstance. This regulation is provided by the autonomic nervous system, including hormones and other secreted factors. In this chapter, we discuss the physiological mechanisms by which cardiac function is controlled and modulated by the autonomic (sympathetic & parasympathetic) nervous system, by the endocrine organs (mainly pituitary and adrenal glands), and, finally, by its own intrinsic endocrine system (cardiac hormones). Particular emphasis is given to molecular receptor signaling mechanisms underlying these processes.

Original languageEnglish (US)
Title of host publicationEndocrinology of the Heart in Health and Disease
Subtitle of host publicationIntegrated, Cellular, and Molecular Endocrinology of the Heart
PublisherElsevier Inc.
Number of pages21
ISBN (Electronic)9780128031124
ISBN (Print)9780128031117
StatePublished - 2017


  • Adrenal gland
  • Aldosterone
  • Angiotensin
  • Autonomic nervous system
  • Cardiac function
  • Catecholamines
  • Neuronal hormones
  • Parasympathetic
  • Signal transduction
  • Sympathetic

ASJC Scopus subject areas

  • Medicine(all)


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