Neuronal GM1 gangliosidosis in a siamese cat with β-galactosidase deficiency

Henry J. Baker; J. Russell Lindsey; Guy M. McKhann; Donald F. Farrell

doi:10.1126/science.174.4011.838

Neuronal GM₁ gangliosidosis in a siamese cat with β-galactosidase deficiency

Henry J. Baker
, J. Russell Lindsey
, Guy M. McKhann
, Donald F. Farrell

Krieger School of Arts and Sciences

Research output: Contribution to journal › Article › peer-review

85 Scopus citations

Abstract

A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM₁ ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM₁ gangliosidosis of children.

Original language	English (US)
Pages (from-to)	838-839
Number of pages	2
Journal	Science
Volume	174
Issue number	4011
DOIs	https://doi.org/10.1126/science.174.4011.838
State	Published - 1971

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title = "Neuronal GM1 gangliosidosis in a siamese cat with β-galactosidase deficiency",

abstract = "A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM1 gangliosidosis of children.",

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AU - Russell Lindsey, J.

AU - McKhann, Guy M.

AU - Farrell, Donald F.

PY - 1971

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AB - A juvenile Siamese cat with severe, progressive motor disability was shown to have extensive neuronal degeneration caused by accumulation of GM1 ganglioside. Tissues from brain and kidney were markedly deficient in β-galactosidase activity. The disease in this cat is thought to be inherited as an autosomal recessive trait, and is strikingly similar to juvenile GM1 gangliosidosis of children.

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AN - SCOPUS:0015146931

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JO - Science

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Neuronal GM₁ gangliosidosis in a siamese cat with β-galactosidase deficiency

Abstract

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