Neuronal density in the superior frontal and temporal gyri does not correlate with the degree of human immunodeficiency virus-associated dementia

Ian P. Everall, Jonathan D. Glass, Justin McArthur, Edward Spargo, Peter Lantos

Research output: Contribution to journalArticlepeer-review

70 Scopus citations

Abstract

Human immune deficiency virus (HIV) disease may be associated, neuropathologically, with significant neuronal loss and clinically with a severe dementia. However, the significance of neuronal loss in the development of dementia has not been established. In this study we have undertaken a stereological determination of the neuronal numerical density and neuronal volumes in post mortem tissue from the superior frontal and superior temporal gyri in 32 patients who died of acquired immune deficiency syndrome (AIDS). All were prospectively clinically characterized, with dementia identified or excluded, and antiretroviral medication documented. This study combines morphometric techniques with prospective clinical assessment of dementia. As previously demonstrated, all patients dying with AIDS showed neuronal loss, but this was not related to the presence of HIV-associated dementia.

Original languageEnglish (US)
Pages (from-to)538-544
Number of pages7
JournalActa neuropathologica
Volume88
Issue number6
DOIs
StatePublished - Dec 1994

Keywords

  • Dementia
  • Human immunodeficiency virus neuronal loss
  • Stereology

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Clinical Neurology
  • Cellular and Molecular Neuroscience

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