Neuronal circuitry mechanisms regulating adult mammalian neurogenesis

Juan Song, Reid H J Olsen, Jiaqi Sun, Guo Li Ming, Hongjun Song

Research output: Contribution to journalArticlepeer-review

50 Scopus citations


The adult mammalian brain is a dynamic structure, capable of remodeling in response to various physiological and pathological stimuli. One dramatic example of brain plasticity is the birth and subsequent integration of newborn neurons into the existing circuitry. This process, termed adult neurogenesis, recapitulates neural developmental events in two specialized adult brain regions: the lateral ventricles of the forebrain. Recent studies have begun to delineate how the existing neuronal circuits influence the dynamic process of adult neurogenesis, from activation of quiescent neural stem cells (NSCs) to the integration and survival of newborn neurons. Here, we review recent progress toward understanding the circuit-based regulation of adult neurogenesis in the hippocampus and olfactory bulb.

Original languageEnglish (US)
Article numbera018937
JournalCold Spring Harbor perspectives in biology
Issue number8
StatePublished - Aug 1 2016

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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