Neuron-glia interactions clarify genetic-environmental links in mental illness

Akira Sawa, Mikhail V. Pletnikov, Atsushi Kamiya

Research output: Contribution to journalShort surveypeer-review

26 Scopus citations


How genes and environment interface to generate major psychiatric disorders such as schizophrenia has been puzzling, as are the relative roles of neurons and glia in such disturbances. Tomonaga and colleagues have recently reported striking neurobehavioral abnormalities in mice expressing Borna disease virus phosphoprotein (BDV-P) selectively in glial cells. The study provides a novel approach of linking environmental and genetic factors to behavior by producing genetically engineered mice. The key role for glial BDV-P implicates neuron-glia interactions in the pathogenesis of psychiatric conditions.

Original languageEnglish (US)
Pages (from-to)294-297
Number of pages4
JournalTrends in neurosciences
Issue number6
StatePublished - Jun 2004

ASJC Scopus subject areas

  • Neuroscience(all)


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