TY - JOUR
T1 - Neurometabolites and associations with cognitive deficits in mild cognitive impairment
T2 - a magnetic resonance spectroscopy study at 7 Tesla
AU - Oeltzschner, Georg
AU - Wijtenburg, S. Andrea
AU - Mikkelsen, Mark
AU - Edden, Richard A.E.
AU - Barker, Peter B.
AU - Joo, Jin Hui
AU - Leoutsakos, Jeannie Marie S.
AU - Rowland, Laura M.
AU - Workman, Clifford I.
AU - Smith, Gwenn S.
N1 - Publisher Copyright:
© 2018 Elsevier Inc.
PY - 2019/1
Y1 - 2019/1
N2 - The levels of several brain metabolites were investigated in the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) in 13 healthy controls (HC) and 13 patients with mild cognitive impairment (MCI) using single-voxel magnetic resonance spectroscopy at 7T. Levels of γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartylglutamate (NAAG), N-acetylaspartate (NAA), and myo-inositol (mI) were quantified relative to total creatine (tCr). The effect of diagnosis on metabolite levels, and relationships between metabolite levels and memory and executive function, correcting for age, were investigated. MCI patients showed significantly decreased GABA/tCr (ACC, PCC), Glu/tCr (PCC), and NAA/tCr (PCC), and significantly increased mI/tCr (ACC). In the combined group, worse episodic verbal memory performance was correlated with lower Glu/tCr (PCC), lower NAA/tCr (PCC), and higher mI/tCr (ACC, PCC). Worse verbal fluency performance was correlated with lower GSH/tCr (PCC). In summary, MCI is associated with decreased GABA and Glu, most consistently in the PCC. Further studies in larger patient samples should be undertaken to determine the utility of 7T magnetic resonance spectroscopy in detecting MCI-related neurochemical changes.
AB - The levels of several brain metabolites were investigated in the anterior cingulate cortex (ACC) and posterior cingulate cortex (PCC) in 13 healthy controls (HC) and 13 patients with mild cognitive impairment (MCI) using single-voxel magnetic resonance spectroscopy at 7T. Levels of γ-aminobutyric acid (GABA), glutamate (Glu), glutathione (GSH), N-acetylaspartylglutamate (NAAG), N-acetylaspartate (NAA), and myo-inositol (mI) were quantified relative to total creatine (tCr). The effect of diagnosis on metabolite levels, and relationships between metabolite levels and memory and executive function, correcting for age, were investigated. MCI patients showed significantly decreased GABA/tCr (ACC, PCC), Glu/tCr (PCC), and NAA/tCr (PCC), and significantly increased mI/tCr (ACC). In the combined group, worse episodic verbal memory performance was correlated with lower Glu/tCr (PCC), lower NAA/tCr (PCC), and higher mI/tCr (ACC, PCC). Worse verbal fluency performance was correlated with lower GSH/tCr (PCC). In summary, MCI is associated with decreased GABA and Glu, most consistently in the PCC. Further studies in larger patient samples should be undertaken to determine the utility of 7T magnetic resonance spectroscopy in detecting MCI-related neurochemical changes.
KW - 7T
KW - Anterior cingulate cortex
KW - GABA
KW - Glutamate
KW - Magnetic resonance spectroscopy
KW - Mild cognitive impairment
KW - Posterior cingulate cortex
UR - http://www.scopus.com/inward/record.url?scp=85055753471&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85055753471&partnerID=8YFLogxK
U2 - 10.1016/j.neurobiolaging.2018.09.027
DO - 10.1016/j.neurobiolaging.2018.09.027
M3 - Article
C2 - 30390554
AN - SCOPUS:85055753471
SN - 0197-4580
VL - 73
SP - 211
EP - 218
JO - Neurobiology of aging
JF - Neurobiology of aging
ER -