TY - JOUR
T1 - Neurological Implications of Zika Virus Infection in Adults
AU - Muñoz, Laura S.
AU - Parra, Beatriz
AU - Pardo, Carlos A.
N1 - Funding Information:
Supplement sponsorship. This work is part of a supplement sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH).
Funding Information:
Financial support. This work was supported by the Bart McLean Fund for Neuroimmunology Research and the Johns Hopkins Project Restore. The Neuroviruses Emerging in the Americas Study is supported in part by the European Union Zika Plan.
Publisher Copyright:
© 2017 The Author(s). Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
PY - 2017
Y1 - 2017
N2 - The 2015-2016 epidemic of Zika virus (ZIKV) in the Americas and the Caribbean was associated with an unprecedented burden of neurological disease among adults. Clinically, Guillain-Barre syndrome (GBS) predominated among regions affected by the ZIKV epidemic, but the spectrum of neurological disease in the adults appears broader as cases of encephalopathy, encephalitis, meningitis, myelitis, and seizures have also been reported. A para-infectious temporal profile of ZIKV-associated GBS (ZIKV-GBS) has been described in clinical studies, which may suggest a direct viral neuropathic effect. However, ZIKV neuropathogenesis has not yet been fully understood. Mechanisms for ZIKV-GBS and other neurological syndromes have been hypothesized, such as adaptive viral genetic changes, immunological interactions with other circulating flaviviruses, and host and factors. This review summarizes the current evidence on ZIKV-associated neurological complications in the adults.
AB - The 2015-2016 epidemic of Zika virus (ZIKV) in the Americas and the Caribbean was associated with an unprecedented burden of neurological disease among adults. Clinically, Guillain-Barre syndrome (GBS) predominated among regions affected by the ZIKV epidemic, but the spectrum of neurological disease in the adults appears broader as cases of encephalopathy, encephalitis, meningitis, myelitis, and seizures have also been reported. A para-infectious temporal profile of ZIKV-associated GBS (ZIKV-GBS) has been described in clinical studies, which may suggest a direct viral neuropathic effect. However, ZIKV neuropathogenesis has not yet been fully understood. Mechanisms for ZIKV-GBS and other neurological syndromes have been hypothesized, such as adaptive viral genetic changes, immunological interactions with other circulating flaviviruses, and host and factors. This review summarizes the current evidence on ZIKV-associated neurological complications in the adults.
KW - Guillain-Barre syndrome
KW - Zika virus
KW - adult population
KW - neurological disease
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U2 - 10.1093/infdis/jix511
DO - 10.1093/infdis/jix511
M3 - Review article
C2 - 29267923
AN - SCOPUS:85040223886
SN - 0022-1899
VL - 216
SP - S897-S905
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
ER -