TY - JOUR
T1 - Neurologic and psychiatric complications of antiretroviral agents
AU - Raines, Charles
AU - Radcliffe, Olivia
AU - Treisman, Glenn J.
PY - 2005/1/1
Y1 - 2005/1/1
N2 - Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.
AB - Advances in highly active antiretroviral therapy (HAART) aim to improve the efficacy of HIV drugs as well as the quality of life in HIV-infected patients. Neurologic and psychologic disturbances that occur because of HIV disease and therapy are of great concern, and because they can overlap and are often difficult to distinguish, their pathogenesis is not clearly understood. Furthermore, these complications can lead to decreased adherence, thereby interfering with treatment outcomes. Antiretrovirals, including nonnucleoside reverse transcriptase inhibitors, can penetrate the central nervous system (CNS) and suppress viral replication, but they can also exacerbate CNS side effects and neuropsychiatric symptoms. When deciding which HAART drug combination is most appropriate for a patient, clinicians must consider the individual's risk of CNS complications together with the efficacy of the specific HAART regimen.
KW - Antiretroviral
KW - HAART
KW - HIV
KW - Neurologic and psychologic complications
UR - http://www.scopus.com/inward/record.url?scp=26944487612&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=26944487612&partnerID=8YFLogxK
U2 - 10.1016/j.jana.2005.07.004
DO - 10.1016/j.jana.2005.07.004
M3 - Article
C2 - 16433108
AN - SCOPUS:26944487612
SN - 1055-3290
VL - 16
SP - 35
EP - 48
JO - Journal of the Association of Nurses in AIDS Care
JF - Journal of the Association of Nurses in AIDS Care
IS - 5
ER -