Neuroimaging of the Philadelphia Neurodevelopmental Cohort

Theodore D. Satterthwaite, Mark A. Elliott, Kosha Ruparel, James Loughead, Karthik Prabhakaran, Monica E. Calkins, Ryan Hopson, Chad Jackson, Jack Keefe, Marisa Riley, Frank D. Mentch, Patrick Sleiman, Ragini Verma, Christos Davatzikos, Hakon Hakonarson, Ruben C. Gur, Raquel E. Gur

Research output: Contribution to journalReview articlepeer-review

236 Scopus citations


The Philadelphia Neurodevelopmental Cohort (PNC) is a large-scale, NIMH funded initiative to understand how brain maturation mediates cognitive development and vulnerability to psychiatric illness, and understand how genetics impacts this process. As part of this study, 1445 adolescents ages 8-21 at enrollment underwent multimodal neuroimaging. Here, we highlight the conceptual basis for the effort, the study design, and the measures available in the dataset. We focus on neuroimaging measures obtained, including T1-weighted structural neuroimaging, diffusion tensor imaging, perfusion neuroimaging using arterial spin labeling, functional imaging tasks of working memory and emotion identification, and resting state imaging of functional connectivity. Furthermore, we provide characteristics regarding the final sample acquired. Finally, we describe mechanisms in place for data sharing that will allow the PNC to become a freely available public resource to advance our understanding of normal and pathological brain development.

Original languageEnglish (US)
Pages (from-to)544-553
Number of pages10
StatePublished - Feb 1 2014
Externally publishedYes


  • Adolescence
  • Brain
  • Connectome
  • Development
  • FMRI
  • MRI
  • Neuroimaging
  • Resting-state

ASJC Scopus subject areas

  • Neurology
  • Cognitive Neuroscience


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