Abstract
BACKGROUND- Certain central nervous system (CNS) lesions can be misconstrued histopathologically as high-grade or aggressive neoplasms when they are, in fact, low-grade processes for which surgery alone may be adequate therapy. Reactive lesions such as demyelinating disease can be misinterpreted as well and when diagnosed as a glioma, may be treated with radiotherapy. Complications of treatment, e.g., radionecrosis, are fostered by the long post-therapy survival periods permitted by low-grade neoplasms and, especially, nonneoplastic entities. REVIEW SUMMARY- As a benchmark against which any diagnosis of a CNS tumor should be reconciled is a set of neuroradiological findings that usually indicate a low-grade neoplasm or a reactive nonneoplastic entity. These eight specific radiological features are illustrated in the context of representative low-grade or nonneoplastic CNS lesions. CONCLUSIONS- An interdisciplinary approach, with reconciliation of any discrepancies between neuroimaging features and the pathological diagnosis, can minimize the possibility that patients with suspected CNS tumors will be overtreated.
Original language | English (US) |
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Pages (from-to) | 293-299 |
Number of pages | 7 |
Journal | Neurologist |
Volume | 5 |
Issue number | 6 |
DOIs | |
State | Published - Nov 1999 |
Keywords
- Brain
- CNS
- Neuroradiology
- Overtreatment
- Tumors
ASJC Scopus subject areas
- Clinical Neurology