Neurogenic ST depression in stroke

H. C. Chua, S. Sen, R. F. Cosgriff, G. Gerstenblith, Jr Beauchamp, M. Oppenheimer S.

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Background: Stroke is occasionally associated with ECG repolarization changes including ST depression. Recent evidence suggests a neurogenic contribution to these abnormalities in stroke patients. Animal studies implicate the insular cortex in cardiovascular control. We describe a patient with a left insular infarct and without cardiac or coronary artery disease, who developed ST depression indicating a neurogenic etiology. Case description: A 48 year-old female, with no risk factors for stroke, developed sudden expressive aphasia. MRI brain showed an infarct in the left insular cortex. Twenty-four hour Holter monitoring on the third day revealed transient ST depression more than 1.5 mm, which was not reproducible on subsequent monitoring. Transesophageal echo-cardiography (TEE) was normal. She had no cardiac symptoms and serial ECGs, cardiac enzymes (CKMB) and adenosine-thallium scan were normal. To-date, there had been no cardiac events like congestive heart failure or myocardial ischemia. Conclusion: These findings suggest neurogenic ST depression is related to the left insular infarct in view of the normal adenosine-thallium scan, non-reproducibility and evanescence of the ST segment changes and lack of associated cardiac symptoms. When neurogenic ST depression is combined with underlying coronary artery disease, it may adversely influence cardiac outcome after stroke. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)44-48
Number of pages5
JournalClinical Neurology and Neurosurgery
Issue number1
StatePublished - 1999
Externally publishedYes


  • Adenosine-thallium scan
  • Holter
  • Insular cortex
  • Neurogenic
  • ST depression
  • Stroke

ASJC Scopus subject areas

  • Surgery
  • Clinical Neurology


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