Neurofibrillary tangles and β-amyloid deposits in Alzheimer's disease

Michel Goedert, Sangram S. Sisodia, Donald L. Price

Research output: Contribution to journalArticlepeer-review

79 Scopus citations


Alzheimer's disease is characterized by the presence of abundant neurofibrillary tangles and β-amyloid deposits in neocortex, hippocampus and amygdala. The major protein components of tangles and plaques have recently been identified. These findings, briefly reviewed here, will allow researchers to design investigations that will lead to an understanding of the pathogenesis of the disease and to the development of new therapeutic approaches that may result in an effective treatment.

Original languageEnglish (US)
Pages (from-to)441-447
Number of pages7
JournalCurrent Opinion in Neurobiology
Issue number3
StatePublished - Oct 1991

ASJC Scopus subject areas

  • Neuroscience(all)


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