Neuroendocrine neoplasms of the sinonasal region

Diana Bell, Ehab Y. Hanna, Randal S. Weber, Franco Demonte, Asterios Triantafyllou, James S. Lewis, Antonio Cardesa, Pieter J. Slootweg, Göran Stenman, Douglas R. Gnepp, Kenneth O. Devaney, Juan P. Rodrigo, Alessandra Rinaldo, Bruce M. Wenig, William H. Westra, Justin A. Bishop, Henrik Hellquist, Jennifer L. Hunt, Kimihide Kusafuka, Bayardo Perez-OrdoñezMichelle D. Williams, Robert P. Takes, Alfio Ferlito

Research output: Contribution to journalReview articlepeer-review

38 Scopus citations


Neuroendocrine neoplasms of the sinonasal region, which are relatively uncommon but clinically very important, are reviewed here in the light of current knowledge. Using a definition for neuroendocrine based on phenotypic, histologic, immunohistochemical, and electron microscopic features rather than histogenetic criteria, sinonasal neuroendocrine carcinomas are examined with a particular emphasis on the small-cell and large-cell subtypes. This is followed by revisiting olfactory neuroblastoma because it is also a tumor that shows a neuroendocrine phenotype. Kadish clinical and Hyams histologic grading systems as prognosticators of olfactory neuroblastoma are also considered in detail. Finally, controversies regarding sinonasal undifferentiated carcinoma as a neuroendocrine tumor are discussed and a possible relationship with high-grade olfactory neuroblastoma is explored. Genetic events and current management of these tumors are also outlined.

Original languageEnglish (US)
Pages (from-to)E2259-E2266
JournalHead and Neck
StatePublished - Apr 1 2016


  • immunohistochemistry
  • neuroendocrine neoplasms
  • olfactory neuroblastoma
  • sinonasal carcinoma
  • sinonasal undifferentiated carcinoma

ASJC Scopus subject areas

  • Otorhinolaryngology


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