Neuroectodermal neoplasms arising in congenital nevi.

M. S. Jerdan, B. A. Cohen, R. R. Smith, A. F. Hood

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


Congenital giant nevi of neuroectodermal origin are composed predominantly of melanocytes and occasional neural elements. Neoplasms arising in such nevi may be morphologically heterogeneous with variable clinical behavior. We report the case of a female infant born with multiple pigmented nevi, including a giant hairy nevus of bathing trunk distribution in which arose a large pedunculated mass involving the sacral region, buttocks, perineum, and left thigh. Within this neoplasm, mixtures of neural crest-derived tissues having both melanocytic (nevus) cell and neural supportive (neuroid of Schwannian) cell differentiation were identified. The neural differentiation, which was seen in the dermis and subcutaneous tissue, had a neurofibromatous appearance and demonstrated multiple pseudomeissnerian corpuscles. In addition, at 16 months of age the child developed a malignant melanoma in the flank region of this congenital giant nevus. The morphologic pluripotentiality of the primitive neural crest derivatives in congenital nevi has only recently been elucidated. These lesions should be regarded as neuroectodermal neoplasms and subclassified according to their differentiating histologic characteristics because prognosis and management are influenced by morphologic determinants.

Original languageEnglish (US)
Pages (from-to)41-48
Number of pages8
JournalThe American Journal of dermatopathology
Volume7 Suppl
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Dermatology


Dive into the research topics of 'Neuroectodermal neoplasms arising in congenital nevi.'. Together they form a unique fingerprint.

Cite this