Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis

Dennis Drotar; Karen Olness; Max Wiznitzer; Lawrence Marum; Laura Guay; David Hom; Grace Svilar; Chris Schatschneider; Joseph Fagan; Christopher Ndugwa; Rebecca Kiziri Mayengo

doi:10.1037/0278-6133.18.2.114

Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis

Dennis Drotar, Karen Olness, Max Wiznitzer, Lawrence Marum, Laura Guay, David Hom, Grace Svilar, Chris Schatschneider, Joseph Fagan, Christopher Ndugwa, Rebecca Kiziri Mayengo

Research output: Contribution to journal › Article › peer-review

42 Scopus citations

Abstract

Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV- 1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV- infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.

Original language	English (US)
Pages (from-to)	114-121
Number of pages	8
Journal	Health Psychology
Volume	18
Issue number	2
DOIs	https://doi.org/10.1037/0278-6133.18.2.114
State	Published - Mar 1999
Externally published	Yes

Keywords

HIV infection
Information-processing ability
Mental development
Motor development
Neurodevelopment
Neurologic status

ASJC Scopus subject areas

Psychiatry and Mental health
General Psychology

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10.1037/0278-6133.18.2.114

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title = "Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis",

abstract = "Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV- 1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV- infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.",

keywords = "HIV infection, Information-processing ability, Mental development, Motor development, Neurodevelopment, Neurologic status",

author = "Dennis Drotar and Karen Olness and Max Wiznitzer and Lawrence Marum and Laura Guay and David Hom and Grace Svilar and Chris Schatschneider and Joseph Fagan and Christopher Ndugwa and Mayengo, {Rebecca Kiziri}",

year = "1999",

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doi = "10.1037/0278-6133.18.2.114",

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AU - Olness, Karen

AU - Wiznitzer, Max

AU - Marum, Lawrence

AU - Guay, Laura

AU - Hom, David

AU - Svilar, Grace

AU - Schatschneider, Chris

AU - Fagan, Joseph

AU - Ndugwa, Christopher

AU - Mayengo, Rebecca Kiziri

PY - 1999/3

Y1 - 1999/3

N2 - Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV- 1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV- infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.

AB - Neurodevelopmental outcomes of human immunodeficiency virus Type 1 (HIV- 1)-infected infants of non-drug-using mothers were assessed in a controlled, prospective study from birth to 24 months with 3 groups: 61 infants of HIV- infected mothers, 234 uninfected infants of HIV-infected mothers (seroreverters), and 115 uninfected infants of uninfected mothers. Compared with seroreverters and uninfected infants, HIV-infected infants demonstrated lower mental and motor development on the Bayley Scales and greater deceleration in their rate of motor development. HIV-infected infants with abnormal neurologic exams had lower motor and mental test scores and lower rates of motor Bayley Scales scores than their HIV-infected counterparts with normal neurologic exams. Contrary to prediction, no group differences in mean performance or growth rates were found on visual information processing on the Fagan Test of Infant Intelligence.

KW - HIV infection

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KW - Mental development

KW - Motor development

KW - Neurodevelopment

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Neurodevelopmental outcomes of Ugandan infants with HIV infection: An application of growth curve analysis

Abstract

Keywords

ASJC Scopus subject areas

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