@article{f57e37a058b2448da6dd8b162e1f812f,
title = "Neurodevelopmental outcome of preterm infants enrolled in myo-inositol randomized controlled trial",
abstract = "Objective: This study evaluates the 24-month follow-up for the NICHD Neonatal Research Network (NRN) Inositol for Retinopathy Trial. Study design: Bayley Scales of Infants Development-III and a standardized neurosensory examination were performed in infants enrolled in the main trial. Moderate/severe NDI was defined as BSID-III Cognitive or Motor composite score <85, moderate or severe cerebral palsy, blindness, or hearing loss that prevents communication despite amplification were assessed. Results: Primary outcome was determined for 605/638 (95%). The mean gestational age was 25.8 ± 1.3 weeks and mean birthweight was 805 ± 192 g. Treatment group did not affect the risk for the composite outcome of death or survival with moderate/severe NDI (60% vs 56%, p = 0.40). Conclusions: Treatment group did not affect the risk of death or survival with moderate/severe NDI. Despite early termination, this study represents the largest RCT of extremely preterm infants treated with myo-inositol with neurodevelopmental outcome data.",
author = "{for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network} and Ira Adams-Chapman and Watterberg, {Kristi L.} and Nolen, {Tracy L.} and Shawn Hirsch and Cole, {Carol A.} and Cotten, {C. Michael} and William Oh and Poindexter, {Brenda B.} and Zaterka-Baxter, {Kristin M.} and Abhik Das and Lacy, {Conra Backstrom} and Scorsone, {Ann Marie} and Duncan, {Andrea F.} and DeMauro, {Sara B.} and Goldstein, {Ricki F.} and Colaizy, {Tarah T.} and Wilson-Costello, {Deanne E.} and Purdy, {Isabell B.} and Hintz, {Susan R.} and Heyne, {Roy J.} and Myers, {Gary J.} and Janell Fuller and Stephanie Merhar and Harmon, {Heidi M.} and Myriam Peralta-Carcelen and Kilbride, {Howard W.} and Maitre, {Nathalie L.} and Vohr, {Betty R.} and Girija Natarajan and Helen Mintz-Hittner and Quinn, {Graham E.} and Wallace, {David K.} and Olson, {Richard J.} and Orge, {Faruk H.} and Irena Tsui and Michael Gaynon and Hutchinson, {Amy K.} and He, {Yu Guang} and Winter, {Timothy W.} and Yang, {Michael B.} and Haider, {Kathryn M.} and Cogen, {Martin S.} and Denise Hug and Bremer, {Don L.} and Donahue, {John P.} and Lucas, {William R.} and Phelps, {Dale L.} and Higgins, {Rosemary D.} and Archer, {Stephanie Wilson} and Allen, {Marilee C.}",
note = "Publisher Copyright: {\textcopyright} 2021, This is a U.S. government work and not under copyright protection in the U.S.; foreign copyright protection may apply.",
year = "2021",
month = aug,
doi = "10.1038/s41372-021-01018-5",
language = "English (US)",
volume = "41",
pages = "2072--2087",
journal = "Journal of Perinatology",
issn = "0743-8346",
publisher = "Nature Publishing Group",
number = "8",
}