TY - JOUR
T1 - Neurobehavioral Mechanisms Influencing the Association Between Generativity, the Desire to Promote Well-Being of Younger Generations, and Purpose in Life in Older Adults at Risk for Alzheimer's Disease
AU - The PREVENT-AD Research Group
AU - Walker, Caitlin S.
AU - Li, Linda
AU - Baracchini, Giulia
AU - Tremblay-Mercier, Jennifer
AU - Spreng, R. Nathan
AU - Geddes, Maiya R.
AU - Aisen, Paul
AU - Anthal, Elena
AU - Appleby, Melissa
AU - Bellec, Pierre
AU - Benbouhoud, Fatiha
AU - Bohbot, Véronique
AU - Brandt, Jason
AU - Breitner, John C.S.
AU - Brunelle, Céline
AU - Chakravarty, Mallar
AU - Cheewakriengkrai, Laksanun
AU - Collins, Louis
AU - Couture, Doris
AU - Craft, Suzanne
AU - Dadar, Mahsa
AU - Daoust, Leslie Ann
AU - Das, Samir
AU - Dauar-Tedeschi, Marina
AU - Dea, Doris
AU - Desrochers, Nicole
AU - Dubuc, Sylvie
AU - Duclair, Guerda
AU - Dufour, Marianne
AU - Eisenberg, Mark
AU - El-Khoury, Rana
AU - Etienne, Pierre
AU - Evans, Alan
AU - Faubert, Anne Marie
AU - Ferdinand, Fabiola
AU - Fonov, Vladimir
AU - Fontaine, David
AU - Francoeur, Renaud
AU - Frenette, Joanne
AU - Gagné, Guylaine
AU - Gauthier, Serge
AU - Geddes, Maiya R.
AU - Gervais, Valérie
AU - Giles, Renuka
AU - Gonneaud, Julie
AU - Gordon, Renee
AU - Greco, Claudia
AU - Hoge, Rick
AU - Hudon, Louise
AU - Leoutsakos, Jeannie Marie
N1 - Publisher Copyright:
© The Author(s) 2024. Published by Oxford University Press on behalf of The Gerontological Society of America.
PY - 2024/6/1
Y1 - 2024/6/1
N2 - Objectives: Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in life remain unknown. This study aims to identify the functional neuroanatomy of generativity and mechanisms linking generativity with purpose in life in at-risk older adults. Methods: Fifty-eight older adults (mean age = 70.8, SD = 5.03, 45 females) with a family history of Alzheimer’s disease (AD) were recruited from the PREVENT-AD cohort. Participants underwent brain imaging and completed questionnaires assessing generativity, social support, and purpose in life. Mediation models examined whether social support mediated the association between generativity and purpose in life. Seed-to-voxel analyses investigated the association between generativity and resting-state functional connectivity (rsFC) to the ventromedial prefrontal cortex (vmPFC) and ventral striatum (VS), and whether this rsFC moderated the relationship between generativity and purpose in life. Results: Affectionate social support mediated the association between generative desire and purpose in life. Generative desire was associated with rsFC between VS and precuneus, and, vmPFC and right dorsolateral prefrontal cortex (rdlPFC). The vmPFC–rdlPFC rsFC moderated the association between generative desire and purpose in life. Discussion: These findings provide insight into how the brain supports complex social behavior and, separately, purpose in life in at-risk aging. Affectionate social support may be a putative target process to enhance purpose in life in older adults. This knowledge contributes to future developments of personalized interventions that promote healthy aging.
AB - Objectives: Generativity, the desire and action to improve the well-being of younger generations, is associated with purpose in life among older adults. However, the neurobehavioral factors supporting the relationship between generativity and purpose in life remain unknown. This study aims to identify the functional neuroanatomy of generativity and mechanisms linking generativity with purpose in life in at-risk older adults. Methods: Fifty-eight older adults (mean age = 70.8, SD = 5.03, 45 females) with a family history of Alzheimer’s disease (AD) were recruited from the PREVENT-AD cohort. Participants underwent brain imaging and completed questionnaires assessing generativity, social support, and purpose in life. Mediation models examined whether social support mediated the association between generativity and purpose in life. Seed-to-voxel analyses investigated the association between generativity and resting-state functional connectivity (rsFC) to the ventromedial prefrontal cortex (vmPFC) and ventral striatum (VS), and whether this rsFC moderated the relationship between generativity and purpose in life. Results: Affectionate social support mediated the association between generative desire and purpose in life. Generative desire was associated with rsFC between VS and precuneus, and, vmPFC and right dorsolateral prefrontal cortex (rdlPFC). The vmPFC–rdlPFC rsFC moderated the association between generative desire and purpose in life. Discussion: These findings provide insight into how the brain supports complex social behavior and, separately, purpose in life in at-risk aging. Affectionate social support may be a putative target process to enhance purpose in life in older adults. This knowledge contributes to future developments of personalized interventions that promote healthy aging.
KW - Prosociality
KW - Resting-state fMRI
KW - Self-transcendence
KW - Ventral striatum
KW - Ventromedial prefrontal cortex
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U2 - 10.1093/geronb/gbae060
DO - 10.1093/geronb/gbae060
M3 - Article
C2 - 38623965
AN - SCOPUS:85194913174
SN - 1079-5014
VL - 79
JO - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
JF - Journals of Gerontology - Series B Psychological Sciences and Social Sciences
IS - 6
M1 - gbae060
ER -