Neuroanatomical correlates of depression in post traumatic brain injury: Preliminary results of a pilot study

Vani Rao; Cynthia A. Munro; Paul Rosenberg; Julianna Ward; Melaine Bertrand; Mahaveer Degoankar; Alena Horská; Dzung Pham; David M. Yousem; Peter B. Barker

doi:10.1176/jnp.2010.22.2.231

Neuroanatomical correlates of depression in post traumatic brain injury: Preliminary results of a pilot study

Vani Rao, Cynthia A. Munro, Paul Rosenberg, Julianna Ward, Melaine Bertrand, Mahaveer Degoankar, Alena Horská, Dzung Pham, David M. Yousem, Peter B. Barker

School of Medicine

Research output: Contribution to journal › Article › peer-review

24 Scopus citations

Abstract

The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.

Original language	English (US)
Pages (from-to)	231-235
Number of pages	5
Journal	Journal of Neuropsychiatry and Clinical Neurosciences
Volume	22
Issue number	2
DOIs	https://doi.org/10.1176/jnp.2010.22.2.231
State	Published - 2010

ASJC Scopus subject areas

General Medicine

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abstract = "The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.",

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AU - Rao, Vani

AU - Munro, Cynthia A.

AU - Rosenberg, Paul

AU - Ward, Julianna

AU - Bertrand, Melaine

AU - Degoankar, Mahaveer

AU - Horská, Alena

AU - Pham, Dzung

AU - Yousem, David M.

AU - Barker, Peter B.

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AB - The authors present preliminary results from a pilot study on patterns of brain injury associated with incident major depression after traumatic brain injury (TBI). Brain metabolite ratios, regional brain volumes, and cognitive performance were compared between 10 subjects with incident major depression post-TBI and seven TBI patients without major depression. TBI-depressed participants performed poorly on tests of frontotemporal functioning, had lower choline/creatine and N-acetylaspartate/creatine ratios in the right basal ganglia and had lower regional brain volumes in the right frontal, left occipital, and temporal lobes. The results suggest a possible role of frontotemporal lobe and basal ganglia pathology in depression after TBI.

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Neuroanatomical correlates of depression in post traumatic brain injury: Preliminary results of a pilot study

Abstract

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