NeuroAIDS, drug abuse, and inflammation: Building collaborative research activities

Joan W. Berman, Monica J. Carson, Linda Chang, Brian M. Cox, Howard S. Fox, R. Gilberto Gonzalez, Glen R. Hanson, Kurt F. Hauser, Wen Zhe Ho, Jau Shyong Hong, Eugene O. Major, William F. Maragos, Eliezer Masliah, Justin C. McArthur, Diane B. Miller, Avindra Nath, James P. O'Callaghan, Yuri Persidsky, Christopher Power, Thomas J. RogersWalter Royal

Research output: Contribution to journalReview articlepeer-review

21 Scopus citations


Neurological complications of human immunodeficiency virus (HIV) infection are a public health problem despite the availability of active antiretroviral therapies. The neuropathogenesis of HIV infection revolves around a complex cascade of events that include viral infection and glial immune activation, monocyte-macrophage brain infiltration, and secretion of a host of viral and cellular inflammatory and neurotoxic molecules. Although there is evidence that HIV-infected drug abusers experience more severe neurological disease, the biological basis for this finding is unknown. A scientific workshop organized by the National Institute on Drug Abuse (NIDA) was held on March 23-24, 2006 to address this question. The goal of the meeting was to bring together basic science and clinical researchers who are experts in NeuroAIDS, glial immunity, drugs of abuse, and/or pharmacology in order to find new approaches to understanding interactions between drug abuse and neuroAIDS. The format of the meeting was designed to stimulate open discussion and forge new multidisciplinary research collaborations. This report includes transcripts of active discussions and short presentations from invited participants. The presentations were separated into sections that included: Glial Biology, Inflammation, and HIV; Pharmacology, Neurotoxicology, and Neuroprotection; NeuroAIDS and Virology; and Virus-Drug and Immune-Drug Interactions. Research priorities were identified. Additional information about this meeting is available through links from the NIDA AIDS Research Program website ( ).

Original languageEnglish (US)
Pages (from-to)351-399
Number of pages49
JournalJournal of Neuroimmune Pharmacology
Issue number4
StatePublished - Dec 2006


  • Brain
  • Drug abuse
  • HIV
  • Inflammation
  • NeuroAIDS
  • SIV

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology and Allergy
  • Immunology
  • Pharmacology


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