Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.

Dandan Zhang; Young Seok Choi; Jai Madhok; Xiaofeng Jia; Matthew Koenig; Nitish Thakor

Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.

Dandan Zhang, Young Seok Choi, Jai Madhok, Xiaofeng Jia, Matthew Koenig, Nitish Thakor

Research output: Contribution to journal › Article › peer-review

Abstract

Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.

Original language	English (US)
Pages (from-to)	5946-5949
Number of pages	4
Journal	Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference
State	Published - 2009
Externally published	Yes

ASJC Scopus subject areas

Computer Vision and Pattern Recognition
Signal Processing
Biomedical Engineering
Health Informatics

Cite this

Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats. / Zhang, Dandan; Choi, Young Seok; Madhok, Jai et al.
In: Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference, 2009, p. 5946-5949.

Research output: Contribution to journal › Article › peer-review

@article{2ff80c3c54d04945ac6a0668c607762d,

title = "Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.",

abstract = "Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.",

author = "Dandan Zhang and Choi, {Young Seok} and Jai Madhok and Xiaofeng Jia and Matthew Koenig and Nitish Thakor",

year = "2009",

language = "English (US)",

pages = "5946--5949",

journal = "Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference",

issn = "1557-170X",

publisher = "Institute of Electrical and Electronics Engineers Inc.",

}

TY - JOUR

T1 - Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.

AU - Zhang, Dandan

AU - Choi, Young Seok

AU - Madhok, Jai

AU - Jia, Xiaofeng

AU - Koenig, Matthew

AU - Thakor, Nitish

PY - 2009

Y1 - 2009

N2 - Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.

AB - Previous research has shown that a characteristic burst-suppression (BS) pattern appears in EEG during the early recovery period following cardiac arrest (CA). To study cortical and subcortical neural activity underlying BS, extracellular activity in the parietal cortex and the centromedian nucleus of the thalamus and extradural EEG were recorded in a rodent CA model. Preliminary results show that during the BS, the cortical firing rate is extraordinarily high, and that bursts in EEG correlate to dense spikes in cortical neurons. An unexpected and novel observation is that 1) thalamic activity reappears earlier than cortical activity following CA, and 2) the correlation coefficient of cortical and thalamic activity rises during BS period. These results will help elucidate the mechanism of brain recovery after CA injury.

UR - http://www.scopus.com/inward/record.url?scp=84903859432&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84903859432&partnerID=8YFLogxK

M3 - Article

C2 - 19965064

SN - 1557-170X

SP - 5946

EP - 5949

JO - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

JF - Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Conference

ER -

Neural signals in cortex and thalamus during brain injury from cardiac arrest in rats.

Abstract

ASJC Scopus subject areas

Other files and links

Fingerprint

Cite this