Network-centric analysis of genetic predisposition in diabetic nephropathy

A. Ntemka, F. Iliadis, N. A. Papanikolaou, D. Grekas

Research output: Contribution to journalArticlepeer-review

13 Scopus citations


Diabetic nephropathy is a serious, long-term complication of diabetes and the leading cause of end-stage renal disease throughout the world. Although this disease is progressively imposing a heavier burden on the health care system, in many aspects it remains poorly understood. In addition to environmental influences, there is abundant evidence in support of genetic susceptibility to microvascular complications of nephropathy in diabetic patients. Familial clustering of phenotypes such as end-stage renal disease, albuminuria and kidney disease have been reported in large scale population studies throughout the world demonstrating strong contribution of inherited factors. Recent genome-wide linkage scans identified several chromosomal regions that are likely to contain diabetic nephropathy susceptibility genes, and association analyses have evaluated positional candidate genes under linkage peaks. In this review we have extracted from the literature the most promising candidate genes thought to confer susceptibility to diabetic nephropathy and mapped them to affected pathways by using network-centric analysis. Several of the top susceptibility genes have been identified as network hubs and bottlenecks suggesting that they might be important agents in the onset of diabetic nephropathy.

Original languageEnglish (US)
Pages (from-to)232-237
Number of pages6
Issue number3
StatePublished - 2011
Externally publishedYes


  • Diabetes
  • ECM
  • Gene ontology
  • Nephropathy
  • Networks
  • Renal structural changes
  • Review

ASJC Scopus subject areas

  • Medicine(all)


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