Network analysis reveals synergistic genetic dependencies for rational combination therapy in Philadelphia chromosome⇓like acute lymphoblastic leukemia

Biochemistry, Genetics and Molecular Biology

• Genetics 100%
• Signal Transduction 50%
• Drug Resistance 50%
• Cell Viability 50%
• Kinase 50%
• Phosphotransferase 50%
• Small Molecule 50%
• Mitogen-Activated Protein Kinase 50%
• Transcriptomics 50%
• Tyrosine Kinase Inhibitor 50%
• Dasatinib 50%
• Ruxolitinib 50%
• STAT5B 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Acute Lymphoblastic Leukemia 100%
• Combination Therapy 100%
• Leukemia 100%
• Malignant Neoplasm 33%
• Cell Viability 33%
• Drug Resistance 33%
• Drug Discovery 33%
• Phosphotransferase 33%
• Protein Tyrosine Kinase Inhibitor 33%
• Dasatinib 33%
• Ruxolitinib 33%
• Venetoclax 33%

Keyphrases

• Genetic Dependency 100%
• Controllability Theory 20%