Neonatal Leukemia

Patrick A. Brown

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Neonates are at risk for 3 major forms of leukemia in the first year of life: acute leukemia, juvenile myelomonocytic leukemia, and transient abnormal myelopoiesis associated with Down syndrome. These disorders are rare but generate interest due to aggressive clinical presentation, suboptimal response to current therapies, and fascinating biology. Each can arise as a result of unique constitutional and acquired genetic events. Genetic insights are pointing the way toward novel therapeutic approaches. This article reviews key epidemiologic, clinical, and molecular features of neonatal leukemias, focusing on risk stratification, treatment, and strategies for developing novel molecularly targeted approaches to improve future outcomes.

Original languageEnglish (US)
Pages (from-to)15-33
Number of pages19
JournalClinics in Perinatology
Issue number1
StatePublished - Mar 2021


  • ALL
  • AML
  • Down syndrome
  • JMML
  • KMT2A
  • Leukemia
  • RAS
  • TAM

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Obstetrics and Gynecology


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