TY - JOUR
T1 - Neonatal hypocalcaemic seizures
T2 - Case report and literature review
AU - Kossoff, Eric H.
AU - Silvia, Mary T.
AU - Maret, Alexander
AU - Carakushansky, Mauri
AU - Vining, Eileen P.G.
PY - 2002
Y1 - 2002
N2 - Seizures during the neonatal period have a broad differential diagnosis, many with a specific treatment and prognosis. In the case reported, a combination of dietary and endocrinologic abnormalities resulted in hypocalcemic seizures, which continued despite aggressive correction of serum ionized calcium levels. Serial electroencephalograms (EEG) performed during the hospitalization were markedly abnormal, and treatment with anticonvulsant drugs was considered given the persistence of seizures despite normalization of serum calcium levels. After 4 days of intravenous calcium administration, the seizure activity resolved, and the patient returned to his normal baseline level of functioning. This case highlights the clinical course of neonatal hypocalcemic seizures, EEG findings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness.
AB - Seizures during the neonatal period have a broad differential diagnosis, many with a specific treatment and prognosis. In the case reported, a combination of dietary and endocrinologic abnormalities resulted in hypocalcemic seizures, which continued despite aggressive correction of serum ionized calcium levels. Serial electroencephalograms (EEG) performed during the hospitalization were markedly abnormal, and treatment with anticonvulsant drugs was considered given the persistence of seizures despite normalization of serum calcium levels. After 4 days of intravenous calcium administration, the seizure activity resolved, and the patient returned to his normal baseline level of functioning. This case highlights the clinical course of neonatal hypocalcemic seizures, EEG findings in several cases, and possible mechanisms for both hypocalcemic precipitation of seizures and anticonvulsant ineffectiveness.
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U2 - 10.1177/088307380201700319
DO - 10.1177/088307380201700319
M3 - Article
C2 - 12026245
AN - SCOPUS:0036018877
SN - 0883-0738
VL - 17
SP - 236
EP - 239
JO - Journal of child neurology
JF - Journal of child neurology
IS - 3
ER -