Neonatal Encephalopathy with Group B Streptococcal Disease Worldwide: Systematic Review, Investigator Group Datasets, and Meta-analysis

Cally J. Tann, Kathryn A. Martinello, Samantha Sadoo, Joy E. Lawn, Anna C. Seale, Maira Vega-Poblete, Neal J. Russell, Carol J. Baker, Linda Bartlett, Clare Cutland, Michael G. Gravett, Margaret Ip, Kirsty Le Doare, Shabir A. Madhi, Craig E. Rubens, Samir K. Saha, Stephanie Schrag, Ajoke Sobanjo-Ter Meulen, Johan Vekemans, Paul T. Heath

Research output: Contribution to journalReview articlepeer-review

29 Scopus citations


Background. Neonatal encephalopathy (NE) is a leading cause of child mortality and longer-term impairment. Infection can sensitize the newborn brain to injury; however, the role of group B streptococcal (GBS) disease has not been reviewed. This paper is the ninth in an 11-article series estimating the burden of GBS disease; here we aim to assess the proportion of GBS in NE cases. Methods. We conducted systematic literature reviews (PubMed/Medline, Embase, Latin American and Caribbean Health Sciences Literature [LILACS], World Health Organization Library Information System [WHOLIS], and Scopus) and sought unpublished data from investigator groups reporting GBS-associated NE. Meta-analyses estimated the proportion of GBS disease in NE and mortality risk. UK population-level data estimated the incidence of GBS-associated NE. Results. Four published and 25 unpublished datasets were identified from 13 countries (N = 10 436). The proportion of NE associated with GBS was 0.58% (95% confidence interval [CI], 0.18%-.98%). Mortality was significantly increased in GBS-associated NE vs NE alone (risk ratio, 2.07 [95% CI, 1.47-2.91]). This equates to a UK incidence of GBS-associated NE of 0.019 per 1000 live births. Conclusions. The consistent increased proportion of GBS disease in NE and significant increased risk of mortality provides evidence that GBS infection contributes to NE. Increased information regarding this and other organisms is important to inform interventions, especially in low- A nd middle-resource contexts.

Original languageEnglish (US)
Pages (from-to)S173-S189
JournalClinical Infectious Diseases
StatePublished - 2017


  • Group B Streptococcus
  • hypoxic-ischemic encephalopathy
  • neonatal encephalopathy
  • newborn
  • therapeutic hypothermia.

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases


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