TY - JOUR
T1 - Neoadjuvant checkpoint blockade for cancer immunotherapy
AU - Topalian, Suzanne L.
AU - Taube, Janis M.
AU - Pardoll, Drew M.
N1 - Publisher Copyright:
Copyright © 2020 The Authors,
PY - 2020/1/31
Y1 - 2020/1/31
N2 - Cancer immunotherapies that target the programmed cell death 1 (PD-1):programmed death-ligand 1 (PD-L1) immune checkpoint pathway have ushered in the modern oncology era. Drugs that block PD-1 or PD-L1 facilitate endogenous antitumor immunity and, because of their broad activity spectrum, have been regarded as a common denominator for cancer therapy. Nevertheless, many advanced tumors demonstrate de novo or acquired treatment resistance, and ongoing research efforts are focused on improving patient outcomes. Using anti–PD-1 or anti–PD-L1 treatment against earlier stages of cancer is hypothesized to be one such solution. This Review focuses on the development of neoadjuvant (presurgical) immunotherapy in the era of PD-1 pathway blockade, highlighting particular considerations for biological mechanisms, clinical trial design, and pathologic response assessments. Findings from neoadjuvant immunotherapy studies may reveal pathways, mechanisms, and molecules that can be cotargeted in new treatment combinations to increase anti–PD-1 and anti–PD-L1 efficacy.
AB - Cancer immunotherapies that target the programmed cell death 1 (PD-1):programmed death-ligand 1 (PD-L1) immune checkpoint pathway have ushered in the modern oncology era. Drugs that block PD-1 or PD-L1 facilitate endogenous antitumor immunity and, because of their broad activity spectrum, have been regarded as a common denominator for cancer therapy. Nevertheless, many advanced tumors demonstrate de novo or acquired treatment resistance, and ongoing research efforts are focused on improving patient outcomes. Using anti–PD-1 or anti–PD-L1 treatment against earlier stages of cancer is hypothesized to be one such solution. This Review focuses on the development of neoadjuvant (presurgical) immunotherapy in the era of PD-1 pathway blockade, highlighting particular considerations for biological mechanisms, clinical trial design, and pathologic response assessments. Findings from neoadjuvant immunotherapy studies may reveal pathways, mechanisms, and molecules that can be cotargeted in new treatment combinations to increase anti–PD-1 and anti–PD-L1 efficacy.
UR - http://www.scopus.com/inward/record.url?scp=85078710390&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85078710390&partnerID=8YFLogxK
U2 - 10.1126/science.aax0182
DO - 10.1126/science.aax0182
M3 - Review article
C2 - 32001626
AN - SCOPUS:85078710390
SN - 0036-8075
VL - 367
JO - Science
JF - Science
IS - 6477
M1 - eaax0182
ER -