Negative signaling in B cells: SHIP Grbs Shc

Susheela Tridandapani, Todd Kelley, Damon Cooney, Madhura Pradhan, K. Mark Coggeshall

Research output: Contribution to journalComment/debatepeer-review

65 Scopus citations


Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.

Original languageEnglish (US)
Pages (from-to)424-427
Number of pages4
JournalImmunology Today
Issue number9
StatePublished - Sep 1997
Externally publishedYes

ASJC Scopus subject areas

  • Immunology


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