TY - JOUR
T1 - Negative signaling in B cells
T2 - SHIP Grbs Shc
AU - Tridandapani, Susheela
AU - Kelley, Todd
AU - Cooney, Damon
AU - Pradhan, Madhura
AU - Coggeshall, K. Mark
PY - 1997/9
Y1 - 1997/9
N2 - Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
AB - Negative signaling in B cells is initiated by co-crosslinking of the antigen receptor and the Fcγ, receptor, resulting in cessation of B-cell signaling events and, in turn, inhibiting B-cell proliferation and antibody secretion. Here, a competitive role is proposed for SHIP in blocking the interaction of ShC with the Grb2-Sos complex of proteins that lead to Ras activation in B cells.
UR - http://www.scopus.com/inward/record.url?scp=0030770336&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0030770336&partnerID=8YFLogxK
U2 - 10.1016/S0167-5699(97)01112-2
DO - 10.1016/S0167-5699(97)01112-2
M3 - Comment/debate
C2 - 9293157
AN - SCOPUS:0030770336
SN - 1471-4906
VL - 18
SP - 424
EP - 427
JO - Trends in Immunology
JF - Trends in Immunology
IS - 9
ER -