Negative Regulation of Hypoxic Responses via Induced Reptin Methylation

Jason S. Lee, Yunho Kim, Ik Soo Kim, Bogyou Kim, Hee June Choi, Ji Min Lee, Hi Jai R. Shin, Jung Hwa Kim, Ji Young Kim, Sang Beom Seo, Ho Lee, Olivier Binda, Or Gozani, Gregg L. Semenza, Minhyung Kim, Keun Il Kim, Daehee Hwang, Sung Hee Baek

Research output: Contribution to journalArticlepeer-review

122 Scopus citations


Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.

Original languageEnglish (US)
Pages (from-to)71-85
Number of pages15
JournalMolecular cell
Issue number1
StatePublished - Jul 2010


  • DNA
  • Humdisease
  • Proteins

ASJC Scopus subject areas

  • Molecular Biology
  • Cell Biology


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