@article{43c140d79fb14d6ba5d0544f54567da7,
title = "Negative Regulation of Hypoxic Responses via Induced Reptin Methylation",
abstract = "Lysine methylation within histones is crucial for transcriptional regulation and thus links chromatin states to biological outcomes. Although recent studies have extended lysine methylation to nonhistone proteins, underlying molecular mechanisms such as the upstream signaling cascade that induces lysine methylation and downstream target genes modulated by this modification have not been elucidated. Here, we show that Reptin, a chromatin-remodeling factor, is methylated at lysine 67 in hypoxic conditions by the methyltransferase G9a. Methylated Reptin binds to the promoters of a subset of hypoxia-responsive genes and negatively regulates transcription of these genes to modulate cellular responses to hypoxia.",
keywords = "DNA, Humdisease, Proteins",
author = "Lee, {Jason S.} and Yunho Kim and Kim, {Ik Soo} and Bogyou Kim and Choi, {Hee June} and Lee, {Ji Min} and Shin, {Hi Jai R.} and Kim, {Jung Hwa} and Kim, {Ji Young} and Seo, {Sang Beom} and Ho Lee and Olivier Binda and Or Gozani and Semenza, {Gregg L.} and Minhyung Kim and Kim, {Keun Il} and Daehee Hwang and Baek, {Sung Hee}",
note = "Funding Information: We thank Y. Shinkai and M. Tachibana for G9a KO ES cells, H. Song for G9a shRNA, and Boehringer Ingelheim for G9a inhibitor. This CRI work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korean government (MEST) (Chromatin Dynamics Research Center, 2009-0081563) to S.H.B., Basic Science Research Program (2009-0075155) and the SRC program (R11-2005-017-04004-0) to K.I.K., and Brain Korea 21 fellowship to J.S.L., Y.K., I.S.K., B.K., H.J.C., J.M.L., and H.-J.R.S. ",
year = "2010",
month = jul,
doi = "10.1016/j.molcel.2010.06.008",
language = "English (US)",
volume = "39",
pages = "71--85",
journal = "Molecular cell",
issn = "1097-2765",
publisher = "Cell Press",
number = "1",
}