Negative chronotropic factor in patients with fungemia

B. A. Rosenfeld, Z. J. Bosnjak, R. M. Shapiro, T. Dorman, B. Ligier, M. J. Breslow

Research output: Contribution to journalArticlepeer-review

3 Scopus citations


Objective: To study the effect of serum from patients with fungemia and control patients on sinoatrial node function. Design: Prospective, observational study. Setting: Surgical ICU in a university hospital. Patients: Fourteen patients with fungemia and 14 control patients. Measurements and Main Results: Serum samples from all patients were assayed in an in vitro sinus node preparation. Serum samples from 11 (78%) of the 14 fungemic patients caused a decrease in sinus node activity, while serum samples from only one (7%) of 14 control patients caused slowing of the sinus node. Conclusions: Serum from many patients with fungemia causes slowing of an in vitro sinus node preparation. This in vitro finding may explain bradyarrhythmias seen clinically in the setting of fungemia.

Original languageEnglish (US)
Pages (from-to)327-331
Number of pages5
JournalCritical care medicine
Issue number3
StatePublished - Jan 1 1992


  • Gram-negative bacteria
  • Gram-positive bacteria
  • action potential
  • arrhythmia
  • bacteremia
  • blood gas analysis
  • bradycardia
  • electrocardiography
  • sinoatrial node

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine


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