Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

P. S. Gao; X. Q. Mao; M. Kawai; T. Enomoto; S. Sasaki; O. Tanabe; K. Yoshimura; S. R. Shaldon; Y. Dake; H. Kitano; P. Coull; T. Shirakawa; J. M. Hopkin

doi:10.1007/s004390050783

Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

P. S. Gao, X. Q. Mao, M. Kawai, T. Enomoto, S. Sasaki, O. Tanabe, K. Yoshimura, S. R. Shaldon, Y. Dake, H. Kitano, P. Coull, T. Shirakawa, J. M. Hopkin

Research output: Contribution to journal › Article › peer-review

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Abstract

The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n = 275) and Japanese (n = 300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.

Original language	English (US)
Pages (from-to)	57-59
Number of pages	3
Journal	Human genetics
Volume	103
Issue number	1
DOIs	https://doi.org/10.1007/s004390050783
State	Published - 1998
Externally published	Yes

ASJC Scopus subject areas

Genetics
Genetics(clinical)

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@article{19f7966c8ee54588809503040f3d6fe4,

title = "Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations",

abstract = "The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n = 275) and Japanese (n = 300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.",

author = "Gao, {P. S.} and Mao, {X. Q.} and M. Kawai and T. Enomoto and S. Sasaki and O. Tanabe and K. Yoshimura and Shaldon, {S. R.} and Y. Dake and H. Kitano and P. Coull and T. Shirakawa and Hopkin, {J. M.}",

note = "Funding Information: Acknowledgements We thank Drs. P. le Souef, C. Hayden and I. Laing (Department of Pediatrics, Western Australia University, Perth) for their kind information and discussion. This work was in part supported by a research grant from Mitsubishi Chemical Co. (Tokyo, Japan).",

year = "1998",

doi = "10.1007/s004390050783",

language = "English (US)",

volume = "103",

pages = "57--59",

journal = "Human genetics",

issn = "0340-6717",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "1",

}

TY - JOUR

T1 - Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

AU - Gao, P. S.

AU - Mao, X. Q.

AU - Kawai, M.

AU - Enomoto, T.

AU - Sasaki, S.

AU - Tanabe, O.

AU - Yoshimura, K.

AU - Shaldon, S. R.

AU - Dake, Y.

AU - Kitano, H.

AU - Coull, P.

AU - Shirakawa, T.

AU - Hopkin, J. M.

N1 - Funding Information: Acknowledgements We thank Drs. P. le Souef, C. Hayden and I. Laing (Department of Pediatrics, Western Australia University, Perth) for their kind information and discussion. This work was in part supported by a research grant from Mitsubishi Chemical Co. (Tokyo, Japan).

PY - 1998

Y1 - 1998

N2 - The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n = 275) and Japanese (n = 300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.

AB - The gene encoding Clara cell-derived inflammatory molecule CC16 has been cited as a candidate gene for atopic asthma on chromosome 11q13. A genetic association study was performed with variants of the CC16 gene on chromosome 11q13 in relation to asthma in British (n = 275) and Japanese (n = 300) populations. No significant association was found between asthma and CC16 genotypes, irrespective of atopic status in these two populations. These data suggest that CC16 might not be the major locus for asthma on 11q13.

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Negative association between asthma and variants of CC16(CC10) on chromosome 11q13 in British and Japanese populations

Abstract

ASJC Scopus subject areas

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