Needles in haystacks: Identifying specific peptide antigens for T cells

Nilabh Shastri

Research output: Contribution to journalArticlepeer-review

25 Scopus citations


The antigen receptors of T cells are engaged by unique peptides displayed by MHC molecules on the antigen-presenting cell surface. These rare peptides can now be distinguished among the thousands normally bound to MHC molecules. Knowledge of the antigenic peptides and their donor proteins is suggesting potential targets for immunotherapy and providing insights into the cellular mechanisms that generate the peptide-MHC complexes.

Original languageEnglish (US)
Pages (from-to)271-277
Number of pages7
JournalCurrent Opinion in Immunology
Issue number2
StatePublished - Apr 1996
Externally publishedYes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology


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