NEDD4-mediated HSF1 degradation underlies α-synucleinopathy

Keyphrases

• Acetylation 8%
• Aggregation-prone Protein 8%
• Alpha-synuclein (α-syn) 25%
• Anti-apoptotic Proteins 8%
• Cellular Proteins 8%
• Common Denominator 8%
• Deacetylation 8%
• DNA-binding Domain 8%
• Dysregulated 8%
• Dysregulation 8%
• E3 Ubiquitin Ligase 8%
• Encoded Protein 8%
• Heat Shock Factor 1 (HSF1) 100%
• Heat Shock Proteins 8%
• Hsp90 Inhibitor 8%
• Human Specimen 8%
• In Situ Study 8%
• In Vivo Assessment 8%
• Misfolded Proteins 8%
• Molecular Chaperone 8%
• NEDD4 100%
• Neuroblastoma Cells 8%
• Neurodegeneration 16%
• Neurodegenerative Mechanisms 8%
• Protein Aggregates 8%
• Protein Chaperone 8%
• Protein Homeostasis 8%
• Protein Stability 8%
• Proteolytic Cascade 8%
• Proteotoxic Stress 8%
• Sirtuin 1 (SIRT1) 8%
• Synucleinopathy 100%
• Therapeutic Potential 8%
• Toxic Stress 8%
• Transcription Factor 8%
• Transcriptional Activity 8%
• Ubiquitin-proteasome System 16%

Biochemistry, Genetics and Molecular Biology

• Acetylation 8%
• Chaperone (Protein) 8%
• Deacetylation 8%
• DNA-binding Domain 8%
• Heat Shock Protein 8%
• Heat Shock Transcription Factor 1 100%
• Hsp90 8%
• In Situ Study 8%
• Mouse 8%
• NEDD4 100%
• Proteasome 16%
• Protein Homeostasis 8%
• Protein Stability 8%
• Sirtuin1 8%
• Synuclein 25%
• Transcription Factors 8%
• Ubiquitin 16%
• Ubiquitin-Conjugating Enzyme 8%