Abstract
Necrotizing enterocolitis (NEC) continues to afflict approximately 7% of preterm infants born weighing less than 1500 g, though recent investigations have provided novel insights into the pathogenesis of this complex disease. The disease has been a major cause of morbidity and mortality in neonatal intensive care units worldwide for many years, and our current understanding reflects exceptional observations made decades ago. In this review, we will describe NEC from a historical context and summarize seminal findings that underscore the importance of enteral feeding, the gut microbiota, and intestinal inflammation in this complex pathophysiology.
Original language | English (US) |
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Pages (from-to) | 11-18 |
Number of pages | 8 |
Journal | Seminars in pediatric surgery |
Volume | 27 |
Issue number | 1 |
DOIs | |
State | Published - Feb 2018 |
Keywords
- Breast milk
- Endotoxin
- Necrotizing enterocolitis
- Neonatal sepsis
- Surgery
- Toll like receptor
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Surgery