TY - JOUR
T1 - Neck circumference is associated with non-traditional cardiovascular risk factors in individuals at low-to-moderate cardiovascular risk
T2 - Cross-sectional analysis of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)
AU - Almeida-Pititto, B.
AU - Silva, I. T.
AU - Goulart, A. C.
AU - Fonseca, M. I.H.
AU - Bittencourt, M. S.
AU - Santos, R. D.
AU - Blaha, M.
AU - Jones, S.
AU - Toth, P. P.
AU - Kulakarni, K.
AU - Lotufo, P. A.
AU - Bensenor, I. M.
AU - Ferreira, S. R.G.
N1 - Funding Information:
The ELSA‑Brasil baseline study was supported by CNPq‑National Research Council (Grants # 01 06 0010.00 RS, 01 06 0212.00 BA, 01 06 0300.00 ES, 01 06 0278.00 MG, 01 06 0115.00 SP, 01 06 0071.00 RJ).
Funding Information:
Bianca de Almeida Pititto, Isis Tande da Silva, Marilia L Fonseca, Alessandra C. Goulart, Michael J. Blaha, Steven Jones, Isabela M. Benseñor, Paulo A. Lotufo and Sandra R G Ferreira declare that they have no competing interests. Marcio S. Bittencourt has received honoraria for consulting and speaker activities from Boston Scientific and research grant support from Sanofi. Raul D. Santos has received honoraria for consulting, speaker activities and research activi‑ ties from: Amgen, Akcea, Astra Zeneca, Biolab, Kowa, Esperion, Merck, Pfizer, Novo‑Nordisk and Sanofi/Regeneron. Peter Toth has received honoraria for consulting or being a member of the speakers’bureau for Amarin, Amgen, AstraZeneca, Kowa, Merck, and Regeneron‑Sanofi. Krishnaji Kulkarni has received honoraria from VAP Diagnostics Laboratory.
Funding Information:
The ELSA‑Brasil baseline study was supported by the Brazilian Ministry of Health (Science and Technology Department) and the Brazilian Ministry of Science and Technology.
Funding Information:
The current work was supported by grant from the São Paulo Research Foundation (Fundação de Amparo à Pesquisa do Estado de São Paulo— FAPESP—Protocol 2010/00074‑6), São Paulo, SP, Brazil.
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/11/20
Y1 - 2018/11/20
N2 - Background: Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36.5; 37.9 and 39.5 cm; women: 31.4; 32.5 and 34 cm) and traditional and non-traditional risk factors (lipoprotein subfractions by Vertical Auto Profile, adiponectin, leptin, E-selectin) were compared across groups. In linear regression models, associations of NC with non-traditional risk factors were tested for the entire sample and for low-risk group (≤ 2 CVRF). Results: In both sexes, BMI, waist circumference, systolic and diastolic blood pressure, fasting and 2-h plasma glucose, HOMA-IR, triglycerides, leptin, E-selectin, small dense LDL-cholesterol, IDL-cholesterol, VLDL3-cholesterol and TG/HDL ratio increased significantly, while HDL2-cholesterol and HDL3-cholesterol decreased across NC quartiles. In linear regression models, a direct association [β(95% CI)] of NC with leptin [(0.155 (0.068-0.242); 0.147 (0.075-0.220)], E-selectin [(0.105 (0.032-0.177); 0.073 (0.006 to 0.140)] and small-dense LDL [(1.866 (0.641-3.091); 2.372 (1.391-3.353)] and an inverse association with HDL2-cholesterol [(- 0.519 (- 0.773 to - 0.266); - 0.815 (- 1.115 to 0.515)] adjusted for age were detected for men and women, respectively. Conclusion: Our findings indicate that measurement of NC may be useful for an earlier identification of unfavorable atherogenic metabolic profile in middle-aged individuals at lower cardiovascular risk level.
AB - Background: Neck circumference (NC) is associated with traditional cardiovascular risk factors (CVRF), but its usefulness to identify earlier atherogenic risk has been scarcely examined. Associations of NC with non-traditional CVRF were investigated in participants at low-to-moderate risk from the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). Methods: 807 individuals (35-54 years) without obesity, diabetes or cardiovascular disease was stratified into quartiles of NC (cut-off for men: 36.5; 37.9 and 39.5 cm; women: 31.4; 32.5 and 34 cm) and traditional and non-traditional risk factors (lipoprotein subfractions by Vertical Auto Profile, adiponectin, leptin, E-selectin) were compared across groups. In linear regression models, associations of NC with non-traditional risk factors were tested for the entire sample and for low-risk group (≤ 2 CVRF). Results: In both sexes, BMI, waist circumference, systolic and diastolic blood pressure, fasting and 2-h plasma glucose, HOMA-IR, triglycerides, leptin, E-selectin, small dense LDL-cholesterol, IDL-cholesterol, VLDL3-cholesterol and TG/HDL ratio increased significantly, while HDL2-cholesterol and HDL3-cholesterol decreased across NC quartiles. In linear regression models, a direct association [β(95% CI)] of NC with leptin [(0.155 (0.068-0.242); 0.147 (0.075-0.220)], E-selectin [(0.105 (0.032-0.177); 0.073 (0.006 to 0.140)] and small-dense LDL [(1.866 (0.641-3.091); 2.372 (1.391-3.353)] and an inverse association with HDL2-cholesterol [(- 0.519 (- 0.773 to - 0.266); - 0.815 (- 1.115 to 0.515)] adjusted for age were detected for men and women, respectively. Conclusion: Our findings indicate that measurement of NC may be useful for an earlier identification of unfavorable atherogenic metabolic profile in middle-aged individuals at lower cardiovascular risk level.
KW - Adipocytokines
KW - Cardiovascular risk factors
KW - E-Selectin
KW - Lipoprotein subfractions
KW - Neck circumference
KW - Non-traditional risk factors
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U2 - 10.1186/s13098-018-0388-4
DO - 10.1186/s13098-018-0388-4
M3 - Article
C2 - 30479668
AN - SCOPUS:85057058999
SN - 1758-5996
VL - 10
JO - Diabetology and Metabolic Syndrome
JF - Diabetology and Metabolic Syndrome
IS - 1
M1 - 82
ER -