Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Shuo Chen; Adam Z. Weitemier; Xiao Zeng; Linmeng He; Xiyu Wang; Yanqiu Tao; Arthur J.Y. Huang; Yuki Hashimotodani; Masanobu Kano; Hirohide Iwasaki; Laxmi Kumar Parajuli; Shigeo Okabe; Daniel B. Loong Teh; Angelo H. All; Iku Tsutsui-Kimura; Kenji F. Tanaka; Xiaogang Liu; Thomas J. McHugh

doi:10.1126/science.aaq1144

Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

Shuo Chen, Adam Z. Weitemier, Xiao Zeng, Linmeng He, Xiyu Wang, Yanqiu Tao, Arthur J.Y. Huang, Yuki Hashimotodani, Masanobu Kano, Hirohide Iwasaki, Laxmi Kumar Parajuli, Shigeo Okabe, Daniel B. Loong Teh, Angelo H. All, Iku Tsutsui-Kimura, Kenji F. Tanaka, Xiaogang Liu, Thomas J. McHugh

School of Medicine

Research output: Contribution to journal › Article › peer-review

407 Scopus citations

Abstract

Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.

Original language	English (US)
Pages (from-to)	679-684
Number of pages	6
Journal	Science
Volume	359
Issue number	6376
DOIs	https://doi.org/10.1126/science.aaq1144
State	Published - Feb 9 2018

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Chen, S., Weitemier, A. Z., Zeng, X., He, L., Wang, X., Tao, Y., Huang, A. J. Y., Hashimotodani, Y., Kano, M., Iwasaki, H., Parajuli, L. K., Okabe, S., Loong Teh, D. B., All, A. H., Tsutsui-Kimura, I., Tanaka, K. F., Liu, X., & McHugh, T. J. (2018). Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics. Science, 359(6376), 679-684. https://doi.org/10.1126/science.aaq1144

Chen, S, Weitemier, AZ, Zeng, X, He, L, Wang, X, Tao, Y, Huang, AJY, Hashimotodani, Y, Kano, M, Iwasaki, H, Parajuli, LK, Okabe, S, Loong Teh, DB, All, AH, Tsutsui-Kimura, I, Tanaka, KF, Liu, X & McHugh, TJ 2018, 'Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics', Science, vol. 359, no. 6376, pp. 679-684. https://doi.org/10.1126/science.aaq1144

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abstract = "Optogenetics has revolutionized the experimental interrogation of neural circuits and holds promise for the treatment of neurological disorders. It is limited, however, because visible light cannot penetrate deep inside brain tissue. Upconversion nanoparticles (UCNPs) absorb tissue-penetrating near-infrared (NIR) light and emit wavelength-specific visible light. Here, we demonstrate that molecularly tailored UCNPs can serve as optogenetic actuators of transcranial NIR light to stimulate deep brain neurons. Transcranial NIR UCNP-mediated optogenetics evoked dopamine release from genetically tagged neurons in the ventral tegmental area, induced brain oscillations through activation of inhibitory neurons in the medial septum, silenced seizure by inhibition of hippocampal excitatory cells, and triggered memory recall. UCNP technology will enable less-invasive optical neuronal activity manipulation with the potential for remote therapy.",

author = "Shuo Chen and Weitemier, {Adam Z.} and Xiao Zeng and Linmeng He and Xiyu Wang and Yanqiu Tao and Huang, {Arthur J.Y.} and Yuki Hashimotodani and Masanobu Kano and Hirohide Iwasaki and Parajuli, {Laxmi Kumar} and Shigeo Okabe and {Loong Teh}, {Daniel B.} and All, {Angelo H.} and Iku Tsutsui-Kimura and Tanaka, {Kenji F.} and Xiaogang Liu and McHugh, {Thomas J.}",

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doi = "10.1126/science.aaq1144",

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AU - Tao, Yanqiu

AU - Huang, Arthur J.Y.

AU - Hashimotodani, Yuki

AU - Kano, Masanobu

AU - Iwasaki, Hirohide

AU - Parajuli, Laxmi Kumar

AU - Okabe, Shigeo

AU - Loong Teh, Daniel B.

AU - All, Angelo H.

AU - Tsutsui-Kimura, Iku

AU - Tanaka, Kenji F.

AU - Liu, Xiaogang

AU - McHugh, Thomas J.

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Near-infrared deep brain stimulation via upconversion nanoparticle–mediated optogenetics

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