Natural killer T (NKT) cells in mice and men

Nicola M. Heller; Rosa Berga-Bolanos; Lynette Naler; Jyoti Misra Sen

doi:10.1201/9781315371689

Natural killer T (NKT) cells in mice and men

Nicola M. Heller, Rosa Berga-Bolanos, Lynette Naler, Jyoti Misra Sen

School of Medicine

Research output: Chapter in Book/Report/Conference proceeding › Chapter

2 Scopus citations

Abstract

Natural killer T (NKT) cells are innate natural killer (NK)-like cells that express a limited repertoire of T cell receptors (TCRs). Akin to other innate cells, NKT cells acquire functional characteristics during development in the thymus. Similar to mature effector T cells, murine NKT cells have been subdivided into effector subsets based on expression of transcription factors Gata3, ROR?t, or Tbet, and by the cytokine expression. In this chapter we have attempted to place the available research on human and murine NKT cells side by side even though making direct connections remains challenging, as research in the two species has progressed independently.

Original language	English (US)
Title of host publication	Signaling Mechanisms Regulating T Cell Diversity and Function
Publisher	CRC Press
Pages	119-146
Number of pages	28
ISBN (Electronic)	9781498705097
ISBN (Print)	9781498705080
DOIs	https://doi.org/10.1201/9781315371689
State	Published - Jan 1 2017

ASJC Scopus subject areas

Medicine(all)
Immunology and Microbiology(all)
Biochemistry, Genetics and Molecular Biology(all)

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Natural killer T (NKT) cells in mice and men

Abstract

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