Huperzine A has been shown to be useful in the treatment of symptoms of dementia of the Alzheimer type. Our initial attempts to synthesize (‐)Huperzine A resulted in the racemic mixture of (−)Huperzine A. We have therefore compared the in vitro and in vivo effects of (±)Huperzine A with those of (−)Huperzine A in rats. The results indicate a similar biological mechanism of action between the two, but that the racemic mixture of (±) Huperzine A has a weaker biological activity than the natural product (−)Huperzine A, presumably due to the presence in the mixture of (+)Huperzine A, which is considerably less potent than the (−)isomer.
|Original language||English (US)|
|Number of pages||3|
|Journal||Annals of the New York Academy of Sciences|
|State||Published - Sep 1993|
ASJC Scopus subject areas
- Biochemistry, Genetics and Molecular Biology(all)
- History and Philosophy of Science