Nationwide study of therapeutic plasma exchange vs intravenous immunoglobulin in Guillain-Barré syndrome

Hind A. Beydoun, May A. Beydoun, Sharmin Hossain, Alan B. Zonderman, Shaker M. Eid

Research output: Contribution to journalArticlepeer-review

1 Scopus citations


Background: We compared outcomes of therapeutic plasma exchange (TPE) vs intravenous immunoglobulin (IVIG) among hospitalized patients diagnosed with Guillain-Barré syndrome (GBS). Methods: In a retrospective cohort study of 6642 records (2637 TPE and 4005 IVIG) from the 2002–2014 Nationwide Inpatient Sample, treatment type was examined as predictor of length of stay, total charges, and in-hospital death, with regression modeling using risk adjustment and propensity scoring to control for confounders. Results: Compared with those receiving IVIG, patients who underwent TPE experienced prolonged hospitalization by approximately 7.5 days, greater hospitalization costs by approximately $46,000, and increased in-hospital death with an odds ratio of 2.78. Results did not change after controlling for confounders through risk adjustment, propensity score adjustment, or matching. Conclusions: TPE may be associated with poorer healthcare utilization outcomes vs IVIG, although confounding by indication could not be ascertained.

Original languageEnglish (US)
Pages (from-to)608-615
Number of pages8
JournalMuscle and Nerve
Issue number5
StatePublished - May 1 2020


  • Guillain-Barré syndrome
  • autoimmunity
  • healthcare utilization
  • immunotherapy
  • intravenous immunoglobulin
  • therapeutic plasma exchange

ASJC Scopus subject areas

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)


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