Nanoscale complexity of phospholipid monolayers investigated by near-field scanning optical microscopy

Jeeseong Hwang; Lukas K. Tamm; Christine Böhm; Tirunelveli S. Ramalingam; Eric Betzig; Michael Edidin

doi:10.1126/science.270.5236.610

Nanoscale complexity of phospholipid monolayers investigated by near-field scanning optical microscopy

Jeeseong Hwang, Lukas K. Tamm, Christine Böhm, Tirunelveli S. Ramalingam, Eric Betzig, Michael Edidin

Krieger School of Arts and Sciences

Research output: Contribution to journal › Article › peer-review

141 Scopus citations

Abstract

Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/ liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside G_M1 in the monolayer.

Original language	English (US)
Pages (from-to)	610-614
Number of pages	5
Journal	Science
Volume	270
Issue number	5236
DOIs	https://doi.org/10.1126/science.270.5236.610
State	Published - 1995

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abstract = "Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/ liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside GM1 in the monolayer.",

author = "Jeeseong Hwang and Tamm, {Lukas K.} and Christine B{\"o}hm and Ramalingam, {Tirunelveli S.} and Eric Betzig and Michael Edidin",

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AU - Hwang, Jeeseong

AU - Tamm, Lukas K.

AU - Böhm, Christine

AU - Ramalingam, Tirunelveli S.

AU - Betzig, Eric

AU - Edidin, Michael

PY - 1995

Y1 - 1995

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AB - Near-field scanning optical microscopy of phospholipid monolayers doped with fluorescent lipid analogs reveals previously undescribed features in various phases, including a concentration gradient at the liquid-expanded/ liquid-condensed domain boundary and weblike structures in the solid-condensed phase. Presumably, the web structures are grain boundaries between crystalline solid lipid. These structures are strongly modulated by the addition of low concentrations of cholesterol and ganglioside GM1 in the monolayer.

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ER -

Nanoscale complexity of phospholipid monolayers investigated by near-field scanning optical microscopy

Abstract

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