Naloxone reduces food intake in humans

M. R. Cohen, R. M. Cohen, D. Pickar, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

42 Scopus citations


Hypotheses generated from animal studies that the endogenous opioid system is an important modulator of food intake suggest that blockade of the system in humans should affect eating behavior. To assess this hypothesis, seven normal volunteers were given 2 mg/kg naloxone or placebo on separate days in a double-blind, random but balanced cross-over experimental design. Compared to placebo, naloxone was found to reduce significantly total food intake from preselected prepared trays served 2.75 and 7.75 hours after drug administration (p

Original languageEnglish (US)
Pages (from-to)132-138
Number of pages7
JournalPsychosomatic Medicine
Issue number2
StatePublished - 1985
Externally publishedYes

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • General Psychology


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