Naloxone decreases neurologic deficits in experimental aortic cross-clamping ischemia

R. C. Kinney, J. W. Holaday, J. W. Harmon

Research output: Contribution to journalArticlepeer-review


Postoperative ischemic paraplegia following aortic operation is an infrequent, but devastating, complication of aortic aneurysm operation. The opioid antagonist, naloxone, has been shown to reduce the severity of neurologic dysfunction following ischemic and traumatic spinal cord injury in various animal models. Utilizing aortic cross-clamping in a rabbit model of ischemic paraplegia, we examined the ability of naloxone HCl to protect the spinal cord from ischemic injury. The segmental blood supply to the rabbit's spinal cord allows reproducible paraplegia following infrarenal aortic occlusion. In the present study, rabbits treated with naxolone had significantly improved neurologic outcomes following temporary aortic occlusion. This suggests that opiate anatagonists may be useful in protecting high-risk patients from surgical post-aortic cross-clamping paraplegia.

Original languageEnglish (US)
Pages (from-to)460-461
Number of pages2
JournalSurgical forum
VolumeVOL. 36
StatePublished - Jan 1 1985
Externally publishedYes

ASJC Scopus subject areas

  • Surgery


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